Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
Table 2
Association of TGFBR3 rs2765888 polymorphism with laboratory biomarkers using the dominant genetic model.
Parameter
TGFBR3 rs2765888 polymorphism
value
CC
T_
Median (IQR)
Median (IQR)
Hemoglobin pattern
Fetal hemoglobin, %
5.70 (1.70–10.78)
4.00 (1.27–8.60)
0.217
S hemoglobin, %
80.90 (54.70–90.25)
76.20 (52.80–85.58)
0.098
Hematological markers
RBC, 106/mL
2.84 (2.49–3.96)
3.29 (2.72–3.95)
0.114
Hemoglobin, g/dL
9.00 (7.90–10.80)
9.60 (8.20–11.10)
0.219
Hematocrit, %
27.00 (23.40–32.20)
28.50 (25.33–33.00)
0.215
MCV, fL
88.85 (80.65–96.33)
85.50 (79.80–94.35)
0.361
MCH, ρg
30.35 (27.35–32.80)
28.65 (26.60–32.05)
0.146
MCHC, g/dL
33.90 (33.20–34.40)
33.70 (33.18–33.90)
0.039
RDW, %
20.80 (18.00–24.20)
20.60 (17.43–23.10)
0.515
Reticulocyte count, /mL
138650 (94770–171380)
140025 (88680–180015)
0.793
WBC, /mL
10600 (8075–13300)
10250 (7800–13150)
0.520
Neutrophils, /mL
4687 (3384–6650)
5550 (3550–6518)
0.403
Eosinophils, /mL
315.00 (153.30–578.80)
351.00 (155.00–548.00)
0.984
Lymphocytes, /mL
3834 (2833–4601)
3164 (2348–4264)
0.050
Monocytes, /mL
900 (600–1313)
818 (500–1158)
0.122
Platelet count, x103/mL
389.00 (289.00–474.00)
332.50 (257.00–422.50)
0.071
Platelet volume average, fL
7.90 (7.40–8.60)
8.10 (7.45–8.60)
0.694
Plateletcrit, %
0.31 (0.23–0.37)
0.27 (0.20–0.31)
0.027
Biochemical markers
TC, mg/dL
124.00 (105.00–145.00)
121.00 (108.80–134.50)
0.633
HDL-C, mg/dL
36.00 (31.00–42.00)
36.50 (32.75–43.00)
0.789
LDL-C, mg/dL
64.00 (50.60–80.60)
59.00 (48.10–77.85)
0.638
VLDL-C, mg/dL
20.20 (14.80–25.40)
19.40 (16.50–23.20)
0.964
Triglycerides, mg/dL
101.00 (74.00–127.00)
97.00 (82.50–116.00)
0.994
Non-HDL-C, mg/dL
85.50 (70.00–104.80)
79.50 (69.75–97.75)
0.537
TC/HDL-C ratio
3.27 (2.75–4.14)
3.22 (2.66–4.16)
0.739
Triglycerides/HDL-C ratio
2.57 (1.84–3.76)
2.61 (1.88–3.46)
0.661
LDL-C/HDL-C ratio
1.76 (1.29–2.32)
1.72 (1.18–2.29)
0.828
Total bilirubin, mg/dL
2.05 (1.26–3.13)
1.82 (1.21–3.42)
0.704
Direct bilirubin, mg/dL
0.35 (0.26–0.50)
0.35 (0.24–0.43)
0.662
Indirect bilirubin, mg/dL
1.63 (0.89–2.74)
1.41 (0.91–3.12)
0.924
LDH, U/L
868.00 (654.00–1239.00)
847.50 (610.80–1265.00)
0.593
ALT, U/L
15.00 (11.00–19.00)
12.00 (9.00–20.00)
0.213
AST, U/L
38.00 (26.00–51.25)
34.50 (22.75–56.75)
0.418
Total protein, g/dL
8.19 (7.72–8.84)
8.27 (7.93–8.90)
0.469
Albumin, g/dL
4.75 (4.57–4.95)
4.86 (4.65–5.02)
0.237
Globulin, g/dL
3.48 (3.03–4.00)
3.42 (3.14–3.94)
0.912
Albumin/globulin ratio
1.38 (1.21–1.58)
1.37 (1.25–1.61)
0.679
Iron, mcg/dL
92.00 (73.75–117.00)
93.00 (62.00–134.50)
0.762
Ferritin, ηg/mL
147.50 (90.68–243.80)
121.20 (45.10–169.80)
0.221
Urea nitrogen, mg/dL
17.00 (13.96–21.00)
18.02 (14.31–21.82)
0.201
Creatinine, mg/dL
0.48 (0.38–0.58)
0.51 (0.39–0.68)
0.147
CRP, mg/L
2.61 (1.73–3.78)
2.39 (1.81–5.89)
0.255
AAT, mg/dL
69.30 (37.60–121.30)
72.00 (38.00–91.30)
0.886
RBC: red blood cells; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; LDH: lactate dehydrogenase; WBC: white blood cells; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; VLDL-C: very low-density lipoprotein cholesterol; AST: aspartate aminotransferase; ALT: alanine aminotransferase; CRP: C reactive protein; AAT: alpha 1-antitrypsin; IQR: interquartile range. Bold values indicate significance at . All values obtained by the Mann–Whitney test, except for those with asterisk (), for which the independent -test was used.
