Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
Table 3
Association of TGFBR3 rs284875 polymorphism with laboratory biomarkers using the recessive genetic model.
Parameter
TGFBR3 rs284875 polymorphism
value
GG
A_
Median (IQR)
Median (IQR)
Hemoglobin pattern
Fetal hemoglobin, %
4.70 (1.30–10.30)
6.20 (2.30–9.80)
0.344
S hemoglobin, %
79.90 (52.00–88.70)
83.55 (56.35–90.13)
0.239
Hematological markers
RBC, 106/mL
2.98 (2.59–3.98)
2.63 (2.40–3.68)
0.090
Hemoglobin, g/dL
9.10 (8.10–11.10)
8.35 (7.77–10.35)
0.183
Hematocrit, %
27.50 (24.00–32.60)
25.70 (22.60–31.05)
0.141
MCV, fL
87.10 (80.30–94.80)
90.35 (82.03–98.30)
0.151
MCH, ρg
29.55 (27.20–32.40)
31.15 (27.60–34.10)
0.152
MCHC, g/dL
33.70 (33.20–34.20)
34.00 (33.28–34.53)
0.193
RDW, %
20.70 (17.90–23.50)
21.70 (17.78–25.45)
0.350
Reticulocyte count, /mL
138650 (94770–179340)
136010 (87075–184758)
0.605
WBC, /mL
10750 (8000–13225)
10100 (7875–13525)
0.489
Neutrophils, /mL
5060 (3461–6600)
4348 (3386–6677)
0.413
Eosinophils, /mL
309.50 (153.80–546.00)
396.50 (162.50–613.50)
0.671
Lymphocytes, /mL
3629 (2723–4508)
3795 (2375–4656)
0.825
Monocytes, /mL
900 (600–1296)
810 (560–1140)
0.686
Platelet count, x103/mL
376.00 (278.00–467.00)
388.50 (273.30–457.00)
0.909
Platelet volume average, fL
8.10 (7.40–8.60)
7.80 (7.37–8.42)
0.256
Plateletcrit, %
0.29 (0.23–0.36)
0.29 (0.19–0.36)
0.704
Biochemical markers
TC, mg/dL
123.00 (108.00–140.00)
118.00 (97.00–140.50)
0.296
HDL-C, mg/dL
37.00 (32.00–43.00)
33.00 (29.00–41.00)
0.180
LDL-C, mg/dL
64.60 (51.55–80.35)
55.20 (44.30–75.30)
0.120
VLDL-C, mg/dL
19.40 (14.60–23.60)
21.00 (16.00–27.60)
0.091
Triglycerides, mg/dL
97.00 (73.00–118.00)
105.00 (80.00–138.00)
0.098
Non-HDL-C, mg/dL
85.00 (72.00–103.00)
81.00 (64.50–107.00)
0.489
TC/HDL-C ratio
3.24 (2.76–4.15)
3.29 (2.73–4.50)
0.629
Triglycerides/HDL-C ratio
2.48 (1.82–3.50)
2.93 (2.31–4.30)
0.022
LDL-C/HDL-C ratio
1.75 (1.33–2.34)
1.78 (1.21–2.20)
0.877
Total bilirubin, mg/dL
2.04 (1.24–3.23)
2.00 (1.40–3.06)
0.786
Direct bilirubin, mg/dL
0.35 (0.24–0.43)
0.39 (0.29–0.54)
0.072
Indirect bilirubin, mg/dL
1.58 (0.89–2.90)
1.48 (1.01–2.78)
0.886
LDH, U/L
856.00 (630.00–1217.00)
954.00 (614.50–1354.00)
0.614
ALT, U/L
14.00 (10.00–19.00)
15.00 (9.25–19.50)
0.841
AST, U/L
37.00 (26.00–50.00)
41.00 (25.50–57.00)
0.899
Total protein, g/dL
8.22 (7.85–8.85)
8.09 (7.51–8.89)
0.427
Albumin, g/dL
4.76 (4.60–4.98)
4.88 (4.50–4.99)
0.858
Globulin, g/dL
3.47 (3.11–3.96)
3.25 (2.98–4.11)
0.437
Albumin/globulin ratio
1.36 (1.22–1.58)
1.42 (1.22–1.61)
0.442
Iron, mcg/dL
92.00 (72.00–120.00)
92.00 (72.50–126.00)
0.921
Ferritin, ηg/mL
145.70 (91.63–214.90)
239.60 (50.93–524.70)
0.272
Urea nitrogen, mg/dL
17.00 (14.00–21.00)
17.99 (14.11–21.07)
0.996
Creatinine, mg/dL
0.48 (0.38–0.60)
0.50 (0.34–0.64)
0.962
CRP, mg/L
2.39 (1.71–3.57)
2.66 (1.87–4.82)
0.240
AAT, mg/dL
71.30 (37.10–113.00)
69.00 (45.20–131.30)
0.444
RBC: red blood cells; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; LDH: lactate dehydrogenase; WBC: white blood cells; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; VLDL-C: very low-density lipoprotein cholesterol; AST: aspartate aminotransferase; ALT: alanine aminotransferase; CRP: C reactive protein; AAT: alpha 1-antitrypsin; IQR: interquartile range. Bold values indicate significance at . All values obtained by the Mann–Whitney test, except for those with asterisk (), for which the independent -test was used.
