Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations

Table 5

Association of TGFBR3 rs2765888, rs284875, and rs2038931 polymorphism and TGFBR3 haplotypes with clinical manifestations in SCD.

Clinical manifestation	Polymorphisms									Haplotypes
	rs2765888		value	rs284875		value	rs2038931		value	GG	Non-GG	value	CGG	Non-CGG	value
	CC	T_		GG	A_; N =34		GG	A_
Acute chest syndrome	28	11	0.485	32	7	0.791	25	14	0.495	19	20	0.529	12	27	0.440
Cholelithiasis	37	6	0.075	33	10	0.465	24	19	0.038	16	27	0.015	13	30	0.364
Infections	85	28	0.744	89	24	0.413	79	34	0.606	61	52	0.763	39	74	0.580
Leg ulcer	12	6	0.327	12	6	0.115	11	7	0.471	8	10	0.434	3	15	0.117
Pneumonia	71	19	0.357	74	16	0.570	66	24	0.162	56	34	0.013	40	50	0.016
Painful crises	88	31	0.354	96	23	0.960	84	35	0.402	67	52	0.222	47	72	0.160
Stroke	10	4	0.745	12	2	0.999	9	5	0.767	7	7	0.805	4	10	0.772
Vaso-occlusive events	34	17	0.063	39	12	0.379	35	16	0.991	27	24	0.972	16	35	0.413

Bold values indicate significance at . All values obtained by the Chi-square, except for those with asterisk (), for which the Fisher’s exact test was used.