Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
Table 6
Association of TGFBR3 GG haplotype with laboratory biomarkers.
Parameter
TGFBR3 GG haplotype
value
GG
Non-GG
Median (IQR)
Median (IQR)
Hemoglobin pattern
Fetal hemoglobin, %
80.10 (52.08–89.88)
80.20 (54.50–88.60)
0.688
S hemoglobin, %
4.50 (1.40–8.60)
6.20 (1.70–11.600)
0.142
Hematological markers
RBC, 106/mL
2.98 (2.57–3.98)
2.90 (2.49–3.71)
0.345
Hemoglobin, g/dL
9.10 (8.00–11.10)
9.10 (8.10–10.73)
0.800
Hematocrit, %
27.00 (23.90–33.00)
27.35 (23.48–32.10)
0.765
MCV, fL
86.20 (80.15–93.85)
90.70 (80.78–97.50)
0.063
MCH, ρg
29.10 (27.03–32.33)
30.95 (27.55–32.85)
0.778
MCHC, g/dL
33.70 (33.20–34.20)
33.80 (33.20–34.40)
0.819
RDW, %
21.30 (18.10–24.40)
20.25 (17.70–23.70)
0.217
Reticulocyte count,/mL
133140 (90480–173360)
142055 (94085–181290)
0.478
WBC, /mL
10800 (8700–13000)
10100 (7650–13550)
0.135
Neutrophils, /mL
5282 (3800–6600)
4348 (3350–6713)
0.091
Eosinophils, /mL
300.00 (176.50–557.80)
326.00 (143.50–572.00)
0.862
Lymphocytes, /mL
3629 (2842–4600)
3700 (2626–4514)
0.591
Monocytes, /mL
900.00 (600.00–1300.00)
805.00 (563.50–1265.00)
0.322
Platelet count, x103/mL
379.00 (281.00–474.00)
383.00 (271.80–462.30)
0.655
Platelet volume average, fL
8.00 (7.50–8.60)
7.95 (7.30–8.60)
0.875
Plateletcrit, %
0.29 (0.23–0.36)
0.28 (0.21–0.36)
0.375
Biochemical markers
TC, mg/dL
127.00 (111.50–145.00)
116.50 (100.30–138.00)
0.019
HDL-C, mg/dL
36.00 (32.00–42.75)
36.00 (31.00–43.75)
0.798
LDL-C, mg/dL
68.40 (52.50–82.60)
57.70 (48.10–77.45)
0.034
VLDL-C, mg/dL
20.60 (16.20–25.40)
17.80 (13.80–23.80)
0.050
Triglycerides, mg/dL
103.50 (81.00–127.50)
89.50 (69.25–118.80)
0.040
Non-HDL-C, mg/dL
90.50 (74.00–106.80)
79.00 (66.25–99.75)
0.024
TC/HDL-C ratio
3.34 (2.83–4.26)
3.20 (2.67–3.88)
0.133
Triglycerides/HDL-C ratio
2.71 (1.93–3.73)
2.47 (1.70–3.30)
0.092
LDL-C/HDL-C ratio
1.80 (1.38–2.43)
1.64 (1.20–2.11)
0.135
Total bilirubin, mg/dL
2.07 (1.26–3.18)
1.86 (1.22–3.14)
0.573
Direct bilirubin, mg/dL
0.25 (0.23–0.45)
0.35 (0.28–0.50)
0.378
Indirect bilirubin, mg/dL
1.67 (0.98–2.90)
1.34 (0.87–2.75)
0.339
LDH, U/L
917.00 (644.50–1304.00)
852.00 (614.00–1137.00)
0.276
ALT, U/L
14.50 (11.00–20.00)
14.00 (10.00–19.00)
0.326
AST, U/L
37.50 (26.00–54.75)
37.00 (24.25–50.75)
0.535
Total protein, g/dL
8.33 (8.01–8.88)
8.09 (7.53–8.82)
0.022
Albumin, g/dL
4.79 (4.60–5.05)
4.74 (4.53–4.94)
0.158
Globulin, g/dL
3.52 (3.19–4.00)
3.27 (2.98–3.94)
0.046
Albumin/globulin ratio
1.35 (1.20–1.50)
1.41 (1.22–1.62)
0.147
Iron, mcg/dL
92.00 (74.00–117.00)
92.00 (70.25–127.00)
0.795
Ferritin, ηg/mL
144.60 (98.60–200.60)
177.30 (72.70–300.40)
0.440
Urea nitrogen, mg/dL
17.19 (14.81–21.00)
15.74 (13.50–21.14)
0.169
Creatinine, mg/dL
0.48 (0.38–0.61)
0.48 (0.38–0.60)
0.999
CRP, mg/L
2.41 (1.67–3.78)
2.57 (1.80–3.53)
0.730
AAT, mg/dL
71.30 (37.35–118.50)
69.05 (38.23–118.30)
0.984
RBC: red blood cells; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; LDH: lactate dehydrogenase; WBC: white blood cells; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; VLDL-C: very-low-density lipoprotein cholesterol; AST: aspartate aminotransferase; ALT: alanine aminotransferase; CRP: C reactive protein; AAT: alpha 1-antitrypsin; IQR: interquartile range. Bold values indicate significance at . All values obtained by the Mann–Whitney test, except for those with asterisk (), for which the independent -test was used.
