Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
Table 7
Association of TGFBR3 CGG haplotype with laboratory biomarkers.
Parameter
TGFBR3 CGG haplotype
value
CGG
Non-CGG
Median (IQR)
Median (IQR)
Hemoglobin pattern
Fetal hemoglobin, %
4.50 (1.70–8.15)
5.85 (1.52–11.70)
0.331
S hemoglobin, %
80.70 (52.00–90.53)
79.70 (55.35–88.20)
0.676
Hematological markers
RBC, 106/mL
2.98 (2.54–3.99)
2.95 (2.53–3.78)
0.681
Hemoglobin, g/dL
9.00 (7.85–11.35)
9.15 (8.10–10.80)
0.958
Hematocrit, %
27.00 (23.70–33.50)
27.40 (23.58–32.10)
0.977
MCV, fL
86.20 (80.05–93.78)
89.75 (80.73–97.03)
0.230
MCH, ρg
29.35 (27.13–32.38)
30.25 (27.40–32.68)
0.242
MCHC, g/dL
33.90 (33.20–34.45)
33.70 (33.20–34.28)
0.304
RDW, %
21.60 (18.10–24.50)
20.40 (17.70–23.70)
0.177
Reticulocyte count, /mL
131100 (106860–170440)
139385 (91350–180125)
0.948
WBC, /mL
10800 (9150–13000)
10300 (7800–13400)
0.152
Neutrophils, /mL
4876 (3750–6650)
4810 (3392–6600)
0.452
Eosinophils, /mL
300.00 (182.00–520.00)
335.00 (146.50–552.50)
0.969
Lymphocytes, /mL
3840 (2943–4640)
3500 (2574–4440)
0.090
Monocytes, /mL
944.00 (597.00–1346.00)
840.50 (575.30–1253.00)
0.209
Platelet count, x103/mL
389.00 (310.50–484.50)
371.50 (267.30–454.80)
0.171
Platelet volume average, fL
7.90 (7.50–8.50)
8.00 (7.30–8.60)
0.989
Plateletcrit, %
0.32 (0.24–0.40)
0.28 (0.21–0.35)
0.046
Biochemical markers
TC, mg/dL
128.00 (112.00–147.00)
119.00 (103.50–138.30)
0.029
HDL-C, mg/dL
36.00 (31.75–42.00)
36.00 (32.00–43.00)
0.645
LDL-C, mg/dL
68.40 (55.40–82.80)
58.50 (48.40–78.00)
0.035
VLDL-C, mg/dL
20.80 (15.45–26.40)
19.10 (14.45–23.50)
0.176
Triglycerides, mg/dL
105.00 (77.50–132.50)
94.00 (72.50–117.00)
0.141
Non-HDL-C, mg/dL
91.00 (76.00–108.00)
79.00 (68.00–101.50)
0.030
TC/HDL-C ratio
3.36 (2.86–4.32)
3.22 (2.67–3.96)
0.134
Triglycerides/HDL-C ratio
2.89 (1.87–3.96)
2.51 (1.82–3.45)
0.086
LDL-C/HDL-C ratio
1.83 (1.41–2.43)
1.68 (1.20–2.20)
0.135
Total bilirubin, mg/dL
2.08 (1.26–3.14)
1.92 (1.25–3.20)
0.657
Direct bilirubin, mg/dL
0.34 (0.23–0.45)
0.36 (0.26–0.49)
0.373
Indirect bilirubin, mg/dL
1.60 (0.96–2.66)
1.47 (0.88–2.79)
0.664
LDH, U/L
886.00 (651.00–1261.00)
855.00 (614.50–1224.00)
0.558
ALT, U/L
15.00 (11.00–18.00)
14.00 (10.00–20.00)
0.675
AST, U/L
36.50 (26.00–49.50)
38.00 (24.00–54.00)
0.855
Total protein, g/dL
8.33 (8.02–8.89)
8.09 (7.66–8.82)
0.055
Albumin, g/dL
4.77 (4.60–5.05)
4.79 (4.59–4.98)
0.625
Globulin, g/dL
3.60 (3.28–4.03)
3.32 (3.00–3.93)
0.022
Albumin/globulin ratio
1.31 (1.20–1.50)
1.40 (1.26–1.61)
0.059
Iron, mcg/dL
88.00 (74.25–105.00)
92.00 (67.50–127.50)
0.363
Ferritin, ηg/mL
142.00 (98.30–219.20)
155.70 (73.25–254.30)
0.931
Urea nitrogen, mg/dL
17.00 (14.70–20.49)
17.10 (14.00–21.89)
0.915
Creatinine, mg/dL
0.48 (0.38–0.59)
0.49 (0.38–0.61)
0.605
CRP, mg/L
2.43 (1.59–3.78)
2.37 (1.80–3.53)
0.780
AAT, mg/dL
65.80 (34.75–121.00)
72.55 (39.20–116.00)
0.566
RBC: red blood cells; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; LDH: lactate dehydrogenase; WBC: white blood cells; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; VLDL-C: very-low-density lipoprotein cholesterol; AST: aspartate aminotransferase; ALT: alanine aminotransferase; CRP: C reactive protein; AAT: alpha 1-antitrypsin; IQR: interquartile range. Bold values indicate significance at . All values obtained by the Mann–Whitney test, except for those with asterisk (), for which the independent -test was used.
