Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
Table 9
Association of occurrence of cholelithiasis with laboratory biomarkers.
Parameter
Cholelithiasis-
Cholelithiasis+
value
Median (IQR)
Median (IQR)
Hemoglobin pattern
Fetal hemoglobin, %
3.50 (1.20–7.50)
7.50 (3.60–13.75)
<0.001
S hemoglobin, %
78.70 (51.93–89.35)
85.40 (78.35–90.45)
0.002
Hematological markers
RBC, 106/mL
3.11 (2.59–3.97)
2.63 (2.33–3.34)
0.003
Hemoglobin, g/dL
9.25 (8.10–11.03)
8.60 (7.60–10.50)
0.130
Hematocrit, %
27.50 (24.00–32.55)
26.00 (22.70–31.80)
0.176
MCV, fL
85.60 (79.80–93.30)
94.30 (88.40–104.80)
<0.001
MCH, ρg
28.80 (26.80–31.80)
32.30 (30.10–35.53)
<0.001
MCHC, g/dL
33.80 (33.23–34.40)
33.70 (33.10–34.10)
0.458
RDW, %
20.80 (17.73–24.15)
20.80 (18.10–24.00)
0.999
Reticulocyte count, /mL
142285 (99920–142285)
123200 (79580–157800)
0.085
WBC, /mL
10800 (8100–13300)
9900 (7400–13200)
0.277
Neutrophils, /mL
5026 (3600–6600)
4200 (3080–6600)
0.096
Eosinophils, /mL
345.00 (163.00–597.00)
288.00 (100.00–444.00)
0.097
Lymphocytes, /mL
3658 (2800–4532)
3800 (2652–4700)
0.626
Monocytes, /mL
915.50 (600.00–1300.00)
784.00 (500.00–1260.00)
0.224
Platelet count, x103/mL
390.00 (289.30–476.00)
352.00 (238.00–462.00)
0.149
Platelet volume average, fL
8.10 (7.50–8.60)
7.90 (7.20–8.60)
0.173
Plateletcrit, %
0.30 (0.23–0.36)
0.28 (0.20–0.32)
0.104
Biochemical markers
TC, mg/dL
126.00 (110.00–145.00)
110.00 (97.00–132.00)
0.012
HDL-C, mg/dL
36.00 (32.00–43.00)
36.00 (32.00–44.00)
0.796
LDL-C, mg/dL
64.70 (52.15–83.15)
53.80 (45.60–75.60)
0.003
VLDL-C, mg/dL
20.20 (15.35–23.90)
17.50 (14.45–25.20)
0.399
Triglycerides, mg/dL
101.00 (77.00–121.00)
88.00 (72.50–125.00)
0.355
Non-HDL-C, mg/dL
90.00 (72.00–106.00)
74.00 (65.00–91.00)
0.007
TC/HDL-C ratio
3.38 (2.78–4.24)
2.97 (2.67–3.23)
<0.001
Triglycerides/HDL-C ratio
2.68 (1.87–3.60)
2.17 (1.76–3.16)
0.110
LDL-C/HDL-C ratio
1.83 (1.38–2.43)
1.41 (1.16–1.76)
<0.001
Total bilirubin, mg/dL
1.89 (1.18–3.00)
2.79 (1.54–3.91)
0.016
Direct bilirubin, mg/dL
0.35 (0.27–0.49)
0.36 (0.24–0.44)
0.880
Indirect bilirubin, mg/dL
1.44 (0.88–2.61)
2.17 (1.21–3.50)
0.010
LDH, U/L
879.00 (618.00–1269.00)
855.00 (673.00–1153.00)
0.873
ALT, U/L
14.00 (10.25–19.00)
15.00 (10.00–19.00)
0.779
AST, U/L
39.00 (26.00–54.00)
35.00 (27.00–52.00)
0.512
Total protein, g/dL
8.21 (7.85–8.85)
8.44 (7.76–9.00)
0.215
Albumin, g/dL
4.79 (4.60–4.97)
4.79 (4.57–5.00)
0.868
Globulin, g/dL
3.43 (3.10–3.90)
3.50 (3.03–4.11)
0.200
Albumin/globulin ratio
1.39 (1.25–1.55)
1.30 (1.12–1.62)
0.380
Iron, mcg/dL
92.00 (74.00–120.80)
94.00 (67.00–124.00)
0.960
Ferritin, ηg/mL
154.40 (72.70–248.00)
148.90 (89.33–410.80)
0.577
Urea nitrogen, mg/dL
18.00 (14.53–21.62)
15.00 (12.76–17.22)
0.002
Creatinine, mg/dL
0.48 (0.38–0.63)
0.48 (0.36–0.57)
0.380
CRP, mg/L
2.37 (1.71–3.71)
2.75 (1.87–4.71)
0.128
AAT, mg/dL
68.20 (37.10–120.00)
73.20 (39.65–100.20)
0.873
RBC: red blood cells; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; LDH: lactate dehydrogenase; WBC: white blood cells; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; VLDL-C: very-low-density lipoprotein cholesterol; AST: aspartate aminotransferase; ALT: alanine aminotransferase; CRP: C reactive protein; AAT: alpha 1-antitrypsin; IQR: interquartile range. Bold values indicate significance at . All values obtained by the Mann–Whitney test, except for those with asterisk (), for which the independent -test was used.
