Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis

Figure 2

Plasma nitric oxide (NO) levels in (a) the normal and experimental groups. NC: normal control group; Sham: sham group; SS: sepsis group with saline injection sacrificed at 6, 12, and 24 h after cecal ligation and puncture (CLP); SA: sepsis group with arginine injection sacrificed at 6, 12, and 24 h after CLP. (b) Experimental groups with the inducible NO synthase (iNOS) inhibitor, L-N (6)-iminoethyl-lysine (L-NIL) administration. SSL: sepsis group with saline plus L-NIL, sacrificed at 6, 12, and 24 h after CLP; SAL: sepsis group with Arg plus L-NIL, sacrificed at 6, 12, and 24 h after CLP. Results are presented as the ; for each group. Differences between groups were analyzed using a one-way ANOVA with Tukey’s post hoc test. Significantly differs from the NC group; ^#significantly differs from the SS groups at the same time point in (a).

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