Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis

Figure 6

Histology and quantification of kidney tissues. Images were assessed using Image-Pro Plus software, and representative histological images are shown at 200x magnification. Microphotographs and semiquantification of H&E staining in (a). NC: normal control group; Sham: sham group; SS: sepsis group with a saline injection sacrificed at 6, 12, and 24 h after cecal ligation and puncture (CLP); SA: sepsis group with an arginine injection sacrificed at 6, 12, and 24 h after CLP; (b) SSL: sepsis group with saline plus L-NIL, sacrificed at 6, 12, and 24 h after CLP; SAL: sepsis group with Arg plus L-NIL, sacrificed at 6, 12, and 24 h after CLP. Results are presented as the ; for each group. Differences between groups were analyzed using a one-way ANOVA with Tukey’s post hoc test. Significantly differs from the NC group (); ^#significantly differs from the SS groups at the same time point ().

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