Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis

Table 1

Kidney injury marker levels and kidney function indicators.

	NGAL (μg/mL)	Creatinine (mg/dL)	BUN (mg/dL)
NC
Sham
SS6
SA6
SS12
SA12		^#	^#
SS24
SA24	^#	^#	^#

The experimental groups consisted of NC: normal control group; Sham: sham group; SS: sepsis group with saline injection sacrificed at 6, 12, and 24 h after cecal ligation and puncture (CLP); SA: sepsis group with arginine injection sacrificed at 6, 12, and 24 h after CLP. BUN: blood urea nitrogen; NGAL: neutrophil gelatinase-associated lipocalin-2. Data were analyzed using a one-way ANOVA with Tukey’s post hoc test and presented as the . Significantly differs from the NC group; ^#significantly differs from the SS groups at the same time point ().