Soluble Intercellular Adhesion Molecule- (sICAM-) 1, Thrombospondin-1, and Vinculin for the Identification of Septic Shock Patients Suffering from an Invasive Fungal Infection

Figure 4

Plasma concentrations of vinculin for the detection of an IFI in patients with septic shock. (a) Plasma concentrations of vinculin were measured by mass spectrometry in patients suffering from septic shock with an invasive fungal infection (IFI, dark grey box), a fungal colonization (light grey box), or without any fungal findings (white box). Plasma samples were collected at the onset of septic shock (T0) and 1 day (T1), 2 days (T2), 7 days (T3), 14 days (T4), 21 days (T5), and 28 days (T6) afterwards. Data in box plots are given as median, 25th percentile, 75th percentile with the 10th as well as 90th percentile at the end of the whiskers. Concerning symbolism and higher orders of significance: , , and . (b) Receiver operating characteristic (ROC) analysis with vinculin in all participating patients at septic shock onset (T0) and 1 day (T1), 2 days (T2), 7 days (T3), and 14 days (T4) afterwards with regard to the prediction of an invasive fungal infection (IFI) up to day 28. Patients suffering from an invasive fungal infection (IFI) represented the target group, whereas both patients with a fungal colonization and patients without any fungal isolates served as controls for this ROC analysis. Abbreviations: AUC: area under the curve; CI: confidence interval. (c) Plasma concentrations of vinculin were measured by mass spectrometry in patients suffering from septic shock with an invasive fungal infection (IFI, dark grey box), a fungal colonization (light grey box), or without any fungal findings (white box). In IFI patients as well as in those with a fungal colonization, plasma concentrations of vinculin are presented for the timepoint of first fungal detection in microbiological samples. In patients with no fungal findings, plasma concentrations of vinculin at septic shock onset are presented. Data in box plots are given as median, 25th percentile, 75th percentile with the 10th as well as 90th percentile at the end of the whiskers. Concerning symbolism and higher orders of significance: , .

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