The Effects of Sidt2 on the Inflammatory Pathway in Mouse Mesangial Cells

<div>Inhibition of Sidt2 gene expression in mouse glomerular mesangial cells increased the level of inflammation. (a, b) Compared with the Sidt2+/+ group, the protein expression of the NF-κB pathway including IKK β, p-IKK α/β, NF-κB p65, p-NF-κB p65, p-IκBα, IκBα, and TNF-α in the Sidt2-/- group increased significantly. (c, d) The protein expression of the JAK/STAT pathway including p-Jak2 and IL6 in the Sidt2-/- group was significantly higher compared with that in the Sidt2+/+ group. 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Mediators of Inflammation

fig2

Figure 2

Figure 2: The Effects of Sidt2 on the Inflammatory Pathway in Mouse Mesangial Cells 