Defects of CTLA-4 Are Associated with Regulatory T Cells in Myasthenia Gravis Implicated by Intravenous Immunoglobulin Therapy

Figure 1

Phenotypic profiles of CD4⁺ T cell subsets reveal underrepresentation of Treg and CTLA-4⁺ Treg in MG patients. Representative FACS analysis of PBMCs from healthy donors and untreated MG patients was shown based on cell surface markers and/or intracellular cytokines for CD4⁺IFN-γ⁺ Th1 cells (a), CD4⁺IL-4⁺ Th2 cells (b), CD4⁺IL-17A⁺ Th17 cells (c), CD4⁺CXCR5⁺PD-1^high Tfh cells (d), CD4⁺CD25⁺FOXP3⁺ Treg cells (e) and CD4⁺CD25⁺FOXP3⁺CTLA-4⁺ Treg cells (f). G. Comparison of the mean frequency of CD4⁺ T cell subsets based on FACS analysis using the aforementioned markers in healthy donors () and untreated MG patients (). Data are expressed as . .

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