Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase

<div>Liver injury. Exemplary HE-stained liver sections from (a–c) WT mice and (d–f) ASM<sup>-/-</sup> mice treated as indicated above the image (scale bars 50 <i>μ</i>m, magnification 200x). Blue arrows indicate vascular congestion in WT; empty sinusoids are indicated by black arrows. Exemplary hepatocytes with granular cytoplasm and lipid inclusions are indicated by green arrows. The liver injury markers (g) aspartate aminotransferase (AST) and (h) alanine aminotransferase (ALT) were measured in the blood plasma. 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22C176 22 126 120 126 240C126 266 127 291 132 310C155 323 189 337 227 337Z"></path></g></svg>.</span> ns: not significant.</div>

Mediators of Inflammation

fig7

Figure 7

Figure 7: Reevaluation of Lung Injury in TNF-Induced Shock: The Role of the Acid Sphingomyelinase 