Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury

Figure 5

Therapeutic effects of mibefradil on LPS-induced lung injury in mice. Mibefradil (20 mg/kg) was injected 30 min after LPS exposure, and mice were sacrificed 6 h after LPS exposure. The total cell counts (a) in BALF, MPO activities (b) in lung tissue, total protein concentration (c) in BALF, extravasation of Evans blue dye (d) in lung tissue, TNF-α (e) and IL-6 (f) levels in BALF, and pathological changes (g) in the lung were measured. All values are (). ^#, compared with vehicle-treated control; , significant compared with LPS alone; , significant compared with LPS alone.

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