Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice

Figure 1

Multiple anesthesia/surgery did not impair spatial reference memory in adult mice. (a) Experimental timeline of surgery procedure and Morris water maze test. Mice in the multiple anesthesia/surgery group underwent surgery every 4 days. After the anesthesia/surgical procedure, training was conducted for 5 days followed by probe tests on day 14. (b) Escape latency to reach the hidden platform during the 5-day training; there was no significant difference between the control group and the multiple surgery group (). (c) Average swimming speed during hidden platform training; there was no significant difference between the control group and the multiple surgery group (). (d) Time spent in the target quadrant during the probe test; there was no significant difference between the control group and the multiple surgery group ( for both control and multiple anesthesia/surgery groups). mA/S: multiple anesthesia/surgery.

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