Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice

Figure 3

Both single and multiple anesthesia/surgery induced the activation of microglia in the hippocampus. (a) Representative photomicrographs of immunofluorescence of microglia (Iba1, green); nucleus was stained with DAPI (blue). (). Scale bar: 200 μM (left) and 100 μM (right). (b) Fluorescence signal intensity was quantified by ImageJ (versus control, for sA/S-6 h, for sA/S-24 h, for sA/S-48 h, for mA/S-6 h, for mA/S-24 h, and for mA/S-48 h). Mean (SEM), one-way ANOVA. sA/S: single anesthesia/surgery; mA/S: multiple anesthesia/surgery.

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