Higher Levels of High-Sensitivity C-Reactive Protein Is Positively Associated with the Incidence of Hyperuricemia in Chinese Population: A Report from the China Health and Retirement Longitudinal Study
Table 4
Stratified analyses for association between high-sensitivity CRP (mg/L) and hyperuricemiaa.
Tertiles of high-sensitivity CRP (mg/L)
trendb
for interactionb
Tertile 1
Tertile 2
Tertile 3
Sex
0.13
Male ()
No. of hyperuricemia
58
91
98
No. of participants
796
808
802
High-sensitivity CRP (mg/L)
0.44 (0.43, 0.44)c
1.00 (0.99, 1.02)
3.29 (3.16, 3.42)
Adjusted model 2d
Reference
1.24 (0.85, 1.83)e
1.19 (0.81, 1.76)
0.59
Female ()
No. of hyperuricemia
33
76
118
No. of participants
1004
1003
1006
High-sensitivity CRP (mg/L)
0.41 (0.40, 0.42)
0.92 (0.91, 0.94)
3.01 (2.90, 3.12)
Adjusted model 2
Reference
1.45 (0.93, 2.30)
1.69 (1.10, 2.66)
0.04
Age
0.37
Age ≥60 years ()
No. of hyperuricemia
44
76
98
No. of participants
762
763
768
High-sensitivity CRP (mg/L)
0.46 (0.45, 0.47)
1.06 (1.04, 1.07)
3.43 (3.30, 3.57)
Adjusted model 2
Reference
1.24 (0.81, 1.92)
1.45 (0.96, 2.21)
0.10
Age <60 years ()
No. of hyperuricemia
53
85
118
No. of participants
1040
1029
1057
High-sensitivity CRP (mg/L)
0.40 (0.39, 0.41)
0.88 (0.87, 0.89)
2.88 (2.78, 2.98)
Adjusted model 2
Reference
1.16 (0.79, 1.71)
1.21 (0.83, 1.78)
0.43
BMI
0.40
Normal BMI ()
No. of hyperuricemia
45
78
99
No. of participants
1056
1060
1062
High-sensitivity CRP (mg/L)
0.37 (0.37, 0.38)
0.81 (0.80, 0.82)
2.91 (2.79, 3.02)
Adjusted model 2
Reference
1.14 (0.76, 1.75)
1.18 (0.78, 1.79)
0.56
High BMI ()
No. of hyperuricemia
33
60
67
No. of participants
532
538
535
High-sensitivity CRP (mg/L)
0.48 (0.47, 0.49)
1.08 (1.06, 1.10)
3.07 (2.94, 3.21)
Adjusted model 2
Reference
1.65 (1.02, 2.70)
1.53 (0.96, 2.49)
0.25
Obesity ()
No. of hyperuricemia
24
28
40
No. of participants
211
213
212
High-sensitivity CRP (mg/L)
0.66 (0.63, 0.68)
1.53 (1.48, 1.57)
4.08 (3.85, 4.32)
Adjusted model 2
Reference
0.83 (0.43, 1.62)
1.07 (0.57, 2.03)
0.63
aCRP: C-reactive protein; BMI: body mass index; HDL: high-density lipoprotein; eGFR: estimate glomerular filtration rate; OR: odds ratio; CI: confidence interval. bAnalysis logistic regression analysis. cLeast square mean (95% confidence interval) (all such values). dAdjusted for age, sex, BMI, education level, smoking status, drinking status, level of income, marital status, fasting blood glucose levels, living area, baseline uric acid, hypertension, total cholesterol, triglycerides, HDL cholesterol, and eGFR. eOdds ratio (95% confidence interval) (all such values).
