IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M

Figure 6

Col1A1, Col3A1, matrix metalloproteinase-13 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) expression in the lungs of wild-type and IL-33-/- mice. C57Bl/6 wild-type (WT) or IL-33-/- mice were endotracheally administered AdDl70 (control) or AdOSM, sacrificed at day 7, and lung homogenates examined for mRNA expression of extracellular matrix genes Col1A1, Col3A1, and matrix proteinase and proteinase inhibitor genes MMP-13 and TIMP-1. Expression was assessed by quantitative real-time PCR. Rel. expr.: relative expression. , , , . .