The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection

Table 3

Univariable and multivariable analysis for overall survival.

Variables	Univariable analysis			Multivariable analysis
	HR	95% CI		HR	95% CI
Age (≤60/>60, years)	1.162	0.693-1.946	0.569
Gender (male/female)	1.300	0.795-2.126	0.295
^†KPS (>80/≤80)	0.841	0.492-1.439	0.527
Smoking status (yes/no)	1.890	1.028-3.476	0.040
Localization (rectum/colon)	0.947	0.575-1.560	0.831
Surgical approach (laparoscopy/open)	0.985	0.601-1.615	0.952
Adjuvant therapy (no/yes)	0.652	0.398-1.069	0.090
^†CEA (≤5/>5, ng/ml)	0.692	0.417-1.147	0.153
Pathological stage (I–II/III–IV)	0.451	0.270-0.755	0.002	0.442	0.236-0.827	0.011
Differentiated degree (high-middle/minor)	0.476	0.262-0.862	0.014
Lymphatic invasion (yes/no)	1.934	1.159-3.227	0.012
Vascular invasion (yes/no)	3.508	1.771-5.279	<0.001	2.182	1.243-3.829	0.007
^†ΔSII (>127.7/≤127.7)	4.281	2.553-7.719	<0.001	4.301	2.517-7.350	<0.001

^†KPS: ∆SII: the change in the systemic immune-inflammation index; KPS: Karnofsky Performance Status; CEA: carcinoembryonic antigen.