The Change of Systemic Immune-Inflammation Index Independently Predicts Survival of Colorectal Cancer Patients after Curative Resection

Table 4

Univariable and multivariable analysis for disease-free survival.

Variables	Univariable analysis			Multivariable analysis
	HR	95% CI		HR	95% CI
Age (≤60/>60, years)	1.100	0.682-1.773	0.696
Gender (male/female)	1.342	0.850-2.119	0.207
^†KPS (>80/≤80)	0.785	0.477-1.293	0.343
Smoking status (yes/no)	1.401	0.832-2.361	0.205
Localization (rectum/colon)	0.824	0.515-1.318	0.420
Surgical approach (laparoscopy/open)	0.929	0.588-1.470	0.754
Adjuvant therapy (no/yes)	0.627	0.395-0.993	0.047	0.415	0.250-0.687	0.001
^†CEA (≤5/>5, ng/ml)	0.818	0.514-1.302	0.396
Pathological stage (I–II/III–IV)	0.512	0.321-0.814	0.005
Differentiated degree (high-middle/minor)	0.624	0.349-1.118	0.113
Lymphatic invasion (yes/no)	1.583	0.994-2.521	0.053
Vascular invasion (yes/no)	3.572	2.118-6.024	<0.001	3.305	1.944-5.620	<0.001
^†ΔSII (>127.7/≤127.7)	4.041	2.514-6.496	<0.001	4.924	2.992-8.102	<0.001

^†KPS: ∆SII: the change in the systemic immune-inflammation index; KPS: Karnofsky Performance Status; CEA: carcinoembryonic antigen.