Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling
Overexpression of USP2 reduced cardiac oxidative stress in response to pressure overload. (a) Representative images of DHE in the ventricular sections (upper). Quantification of DHE fluorescence intensity (lower). (b) qPCR analysis of the mRNA expression of NOX2, NOX4, and p22phox in heart tissues from AAV9-Control or AAV9-USP2-treated mice following sham or TAC. All values are presented as the relative value of the sham (AAV9-Control) value. and (AAV9-Control plus TAC vs. AAV9-Control plus sham); # and ## (AAV9-Control plus TAC vs. AAV9-USP2 plus TAC). /group.