Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury

Figure 1

Closed-head weight drop-induced neuroinflammation. Representative images of (a) whole brains and 0.1% crystal violet staining indicate hemorrhage/inflammatory changes (b) in TBI brains as compared to sham control mouse brains ( mice/group). Representative microphotographs show increased GFAP immunoreactivity indicating an increased number of activated astrocytes in TBI mice (72 h) as compared to sham control mice (c). Image magnifications: (b) 200x and (c) 630x.

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