IκB Kinase Inhibitor VII Modulates Sepsis-Induced Excessive Inflammation and Cardiac Dysfunction in 5/6 Nephrectomized Mice

Table 2

Effects of LPS treatment or CLP on hepatic injury and renal function in 5/6 nephrectomized mice.

Parameter	5/6 nephrectomized mice (sham)		5/6 nephrectomized mice
	PBS treated ()	LPS (2 mg/kg) treated ()	PBS treated ()	LPS (2 mg/kg) treated ()
Urea (mM/L)			^a	^a,b
Creatinine (μM/L)			^a	^a,b
ALT (U/L)				^a,b
	Sham operated ()	CLP ()	Sham operated ()	CLP ()
Urea (mM/L)				^a,b
Creatinine (μM/L)				^a
ALT (U/L)				^a,b

The blood creatinine, urea, and ALT levels were analyzed at 18 hrs in mice treated with LPS (2 mg/kg) and at 24 hrs in mice subjected to CLP. The results are presented as . One-way ANOVA was done followed by Bonferroni post hoc test. ^a against the 5/6 nephrectomy group with mentioned treatment. ^b against the respective PBS or sham group.