The Expression Pattern and Regulatory Mechanism of the G0/G1 Switch Gene 2 (G0S2) in the Pathogenesis and Treatment of AChR Myasthenia Gravis (MG)

Figure 5

NFAT5 inhibit G0S2 expression through island 1. (a) The relative mRNA expression level of NFAT family in healthy human and MG patients. The -coordinate represents the relative expression level, MG means the myasthenia gravis patients, and ctrl means healthy volunteers. (b) Upregulation NFAT5 inhibits G0S2 expression. The -coordinate represents the relative expression level of G0S2; the -coordinate represents the different concentrations P-EGF-N1-NFAT5 plasmid which were transfected into T cells. (c) NFAT5 binds island 1 of G0S2 promoter region detected by dual-Luciferase reporter. Full length represents the plasmid containing islands 1 and 2; islands 1 and 2 represent the plasmid containing the corresponding CpG island sequence from G0S2 promoter.

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