The Expression Pattern and Regulatory Mechanism of the G0/G1 Switch Gene 2 (G0S2) in the Pathogenesis and Treatment of AChR Myasthenia Gravis (MG)
NFAT5 inhibit G0S2 expression through island 1. (a) The relative mRNA expression level of NFAT family in healthy human and MG patients. The -coordinate represents the relative expression level, MG means the myasthenia gravis patients, and ctrl means healthy volunteers. (b) Upregulation NFAT5 inhibits G0S2 expression. The -coordinate represents the relative expression level of G0S2; the -coordinate represents the different concentrations P-EGF-N1-NFAT5 plasmid which were transfected into T cells. (c) NFAT5 binds island 1 of G0S2 promoter region detected by dual-Luciferase reporter. Full length represents the plasmid containing islands 1 and 2; islands 1 and 2 represent the plasmid containing the corresponding CpG island sequence from G0S2 promoter.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.