Research Article
Systemic Administration of Calea pinnatifida Inhibits Inflammation Induced by Carrageenan in a Murine Model of Pulmonary Neutrophilia
Table 3
Effects of CE, fractions, and isolated compounds of C. pinnatifida upon tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-17A (IL-17A) in a murine model of carrageenan-induced pleurisy.
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Crude extract (CE: 50 mg/kg), hexane fraction (Hex: 25 mg/kg), methanol fraction (MeOH: 10 mg/kg), ethyl acetate fraction (EtOAc: 5 mg/kg), 3,5-di-O-E-caffeoylquinic acid (3,5-diCQA: 2.5 mg/kg), and 4,5-di-O-E-caffeoylquinic acid (4,5-diCQA: 5 mg/kg) obtained from C. pinnatifida leaves administered 0.5 h before pleurisy induction. Sal: negative control group, animals treated only with sterile saline (0.95%); Cg: positive control group, animals treated only with carrageenan (1%); Dex: animals treated with dexamethasone (0.5 mg/kg) 0.5 h before pleurisy induction; Indo: animals treated with indomethacin (5 mg/kg) 0.5 h before pleurisy induction. aAdministered by intra-pleural route (i.pl.). bAdministered by intra-peritoneal route (i.p.). Each group represents the of six animals. and . |