Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells

Figure 3

Knockdown of IL6 in human endothelial cells lead to identification of a large number of novel IL6-regulated genes. Comparison of lists of genes differentially regulated after IL6 knockdown in human endothelial cells with lists of known interaction partners of IL6 found in public databases (the Ingenuity Knowledge Base® (IPA) and the STRING database). Numbers in intercepts stand for known interaction partners of IL6 found in either IPA or in STRING and differentially regulated by IL6 knockdown in human endothelial cells in our experiments. Numbers outside intersections represent known interaction partners for IL6 found in IPA or STRING but not differentially regulated after IL6 knockdown (in purple) and differentially regulated genes after IL6 knockdown not described as interaction partners in IPA or STRING (in blue). (a) All differentially regulated genes after IL6 knockdown (). (b) The top 10% most up- or downregulated genes after IL6 knockdown.

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(b)