Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells

Table 1

Knockdown of IL6 in human endothelial cells affect biofunctions related to cardiovascular system development and function. Using Ingenuity Pathway Analysis (IPA), biofunctions regulated by IL6 knockdown in human endothelial cells were evaluated. Activated functions are indicated in orange. Functions with Benjamini-Hochberg’s estimated and or >2 were considered as enriched.

IPA biofunctions annotation	-score	value	FDR	No. of molecules
Interaction of vascular endothelial cells	3.130			32
Binding of vascular endothelial cells	2.993			31
Adhesion of vascular endothelial cells	2.552			23
Binding of endothelial cells	2.414			40
Interaction of endothelial cells	2.404			42