Molecularly Distinct NLRP3 Inducers Mediate Diverse Ratios of Interleukin-1β and Interleukin-18 from Human Monocytes

Figure 5

ATP, chitosan, and SiO₂ induce release of IL-1β and IL-18 in primary monocytes. Primary human monocytes were isolated from peripheral blood from healthy volunteers. The release of IL-1β and IL-18 was measured after stimulation with 10 nM ATP, 10 ng/mL chitosan, or 10 ng/mL SiO₂ from LPS-primed cells (10 ng/mL) (a). The IL-18 : IL-1β ratios were calculated (b). Data are shown as from six individual experiments.

(a)

(b)