Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis

Figure 1

Schematic summary of experimental design and timeline. Septic and sham-septic animals underwent laparotomy (see text for details). At 18 h, after reopening the peritoneal cavity, removing the cecum in septic animals, and washing and closing the cavity, surviving septic, sham-septic, and healthy animals were randomly assigned to four groups and placed into a sealed Plexiglas cage continuously flushed with 21% (medical air), 40%, 60%, and 100% of oxygen. After 24 h, surviving animals were euthanized and samples were collected.