Systemic Effects Induced by Hyperoxia in a Preclinical Model of Intra-abdominal Sepsis

Figure 3

Biomarkers of organ damage in serum from septic, sham-septic, and healthy rats. Septic animals underwent cecal ligation and puncture (CLP). All animals were treated for 24 h with 21% (medical air), 40%, 60%, or 100% oxygen. Serum levels of creatinine (a), urea (b), ALAT (c), ASAT (d), troponin (e), and CK (f) are shown. Data are box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile, and largest observation (-12 for septic, for sham-septic, and for healthy animals per group). ALAT: alanine transaminase; ASAT: aspartate aminotransferase; CK: creatine kinase. , , and by the Mann–Whitney test with Bonferroni correction.

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