Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients

Table 1

Genotype distribution and allele frequency of IL-22 SNPs among malaria patients compared to healthy control subjects.

SNPs	Genotype/allele distribution	Control	Patients	OR (95% CI)	^2	value
rs976748	TT	193 (96.5%)	236 (94.4%)	Ref
	CT	6 (3%)	13 (5.2%)	1.772 (0.661-4.749)	1.33	0.249
	CC	1 (0.5%)	1 (0.4%)	0.818 (0.051-13.160)	0.02	0.886
	T	392 (98%)	485 (97%)	1.515 (0.636-3.611)	0.89	0.344
	C	8 (2%)	15 (3%)
	CC+CT vs. TT			1.636 (0.647-4.133)	1.1	0.293
	CC vs. CT+TT			1.251 (0.078-20.130)	0.03	0.874
rs1179246	CC	55 (27.5%)	86 (34.4%)	Ref
	AC	98 (49%)	112 (44.8%)	0.731 (0.474-1.128)	2.01	0.155
	AA	47 (23.5%)	52 (20.8%)	0.708 (0.421-1.190)	1.71	0.191
	C	208 (52%)	284 (56.8%)	0.824 (0.633-1.073)	2.07	0.150
	A	192 (48%)	216 (43.2%)
	AA+AC vs. CC			0.723 (0.482-1.085)	2.46	0.116
	AA vs. AC+CC			0.855 (0.547-1.338)	0.47	0.492
rs2046068	AA	104 (52%)	114 (45.6%)	Ref
	AC	76 (38%)	111 (44.4%)	1.332 (0.898-1.977)	2.03	0.153
	CC	20 (10%)	25 (10%)	1.140 (0.598-2.174)	0.16	0.689
	A	284 (71%)	339 (67.8%)	1.163 (0.873-1.548)	1.07	0.301
	C	116 (29%)	161 (32.2%)
	CC+AC vs. AA			1.292 (0.890-1.876)	1.82	0.177
	CC vs. AC+AA			1.000 (0.538-1.859)	0	1
rs1182844	TT	83 (41.5%)	90 (36%)	Ref
	AT	95 (47.5%)	120 (48%)	1.165 (0.779-1.741)	0.55	0.456
	AA	22 (11%)	40 (16%)	1.677 (0.921-3.054)	2.88	0.089
	T	261 (65.3%)	300 (60%)	1.252 (0.953-1.644)	2.61	0.106
	A	139 (34.5%)	200 (40%)
	AA+AT vs. TT			1.261 (0.861-1.848)	1.42	0.233
	AA vs. AT+TT			1.541 (0.883-2.690)	2.34	0.126
rs2227508	AA	140 (70)	166 (66.4%)	Ref
	AT	56 (28)	71 (28.4%)	1.069 (0.705-1.621)	0.1	0.752
	TT	4 (2)	13 (5.2%)	2.741 (0.874-8.596)	3.22	0.072
	A	336 (84)	403 (80.6%)	1.264 (0.893-1.788)	1.75	0.186
	T	64 (16)	97 (19.4%)
	TT+AT vs. AA			1.181 (0.791-1.762)	0.66	0.415
	TT vs. AT+AA			2.333 (0.750-7.264)	3.13	0.076
rs2227478	TT	84 (42%)	100 (40%)	Ref
	CT	82 (41%)	115 (46%)	1.178 (0.785-1.767)	0.63	0.428
	CC	34 (17%)	35 (14%)	0.865 (0.497-1.505)	0.26	0.606
	T	250 (62.5%)	315 (63%)	0.979 (0.746-1.285)	0.02	0.877
	C	150 (37.5%)	185 (37%)
	CC+CT vs. TT			1.086 (0.744-1.585)	0.18	0.668
	CC vs. CT+TT			0.795 (0.476-1.328)	0.77	0.380
rs2227481	CC	126 (63%)	175 (70%)	Ref
	CT	57 (28.5%)	69 (27.6%)	0.872 (0.573-1.325)	0.41	0.520
	TT	17 (8.5%)	6 (2.4%)	0.254(0.097-0.663)	8.9	0.002
	C	309 (77.3%)	419 (83.8%)	0.656 (0.470-0.916)	6.17	0.013
	T	91 (22.7%)	81 (16.2%)
	TT+CT vs. CC			0.730 (0.492-1.083)	2.46	0.116
	TT vs. CT+CC			0.265 (0.102-0.685)	8.52	0.003
rs2227491	AA	60 (30%)	72 (28.8%)	Ref
	AG	83 (41.5%)	123 (49.2%)	1.235 (0.794-1.920)	0.88	0.348
	GG	57 (28.5%)	55 (22%)	0.804 (0.485-1.332)	0.72	0.396
	A	203 (50.8%)	267 (53.4%)	0.899 (0.691-1.170)	0.63	0.429
	G	197 (49.2%)	233 (46.6%)
	GG+AG vs. AA			1.060 (0.705-1.593)	0.08	0.781
	GG vs. AG+AA			0.708 (0.461-1.086)	2.51	0.113
rs2227483	TT	153 (76.5%)	204 (81.6%)	Ref
	AT	26 (13%)	13 (5.2%)	0.375 (0.187-0.754)	8.05	0.004
	AA	21 (10.5%)	33 (13.2%)	1.179 (0.656-2.117)	0.3	0.582
	T	332 (83%)	421 (84.2%)	0.916 (0.643-1.306)	0.23	0.628
	A	68 (17%)	79 (15.8%)
	AA+AT vs. TT			0.734 (0.465-1.160)	1.76	0.184
	AA vs. AT+TT			1.296 (0.724-2.319)	0.77	0.381