Research Article
Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients
Table 1
Genotype distribution and allele frequency of IL-22 SNPs among malaria patients compared to healthy control subjects.
| SNPs | Genotype/allele distribution | Control | Patients | OR (95% CI) | 2 | value |
| rs976748 | TT | 193 (96.5%) | 236 (94.4%) | Ref | | | CT | 6 (3%) | 13 (5.2%) | 1.772 (0.661-4.749) | 1.33 | 0.249 | CC | 1 (0.5%) | 1 (0.4%) | 0.818 (0.051-13.160) | 0.02 | 0.886 | T | 392 (98%) | 485 (97%) | 1.515 (0.636-3.611) | 0.89 | 0.344 | C | 8 (2%) | 15 (3%) | CC+CT vs. TT | | | 1.636 (0.647-4.133) | 1.1 | 0.293 | CC vs. CT+TT | | | 1.251 (0.078-20.130) | 0.03 | 0.874 |
| rs1179246 | CC | 55 (27.5%) | 86 (34.4%) | Ref | | | AC | 98 (49%) | 112 (44.8%) | 0.731 (0.474-1.128) | 2.01 | 0.155 | AA | 47 (23.5%) | 52 (20.8%) | 0.708 (0.421-1.190) | 1.71 | 0.191 | C | 208 (52%) | 284 (56.8%) | 0.824 (0.633-1.073) | 2.07 | 0.150 | A | 192 (48%) | 216 (43.2%) | AA+AC vs. CC | | | 0.723 (0.482-1.085) | 2.46 | 0.116 | AA vs. AC+CC | | | 0.855 (0.547-1.338) | 0.47 | 0.492 |
| rs2046068 | AA | 104 (52%) | 114 (45.6%) | Ref | | | AC | 76 (38%) | 111 (44.4%) | 1.332 (0.898-1.977) | 2.03 | 0.153 | CC | 20 (10%) | 25 (10%) | 1.140 (0.598-2.174) | 0.16 | 0.689 | A | 284 (71%) | 339 (67.8%) | 1.163 (0.873-1.548) | 1.07 | 0.301 | C | 116 (29%) | 161 (32.2%) | CC+AC vs. AA | | | 1.292 (0.890-1.876) | 1.82 | 0.177 | CC vs. AC+AA | | | 1.000 (0.538-1.859) | 0 | 1 |
| rs1182844 | TT | 83 (41.5%) | 90 (36%) | Ref | | | AT | 95 (47.5%) | 120 (48%) | 1.165 (0.779-1.741) | 0.55 | 0.456 | AA | 22 (11%) | 40 (16%) | 1.677 (0.921-3.054) | 2.88 | 0.089 | T | 261 (65.3%) | 300 (60%) | 1.252 (0.953-1.644) | 2.61 | 0.106 | A | 139 (34.5%) | 200 (40%) | AA+AT vs. TT | | | 1.261 (0.861-1.848) | 1.42 | 0.233 | AA vs. AT+TT | | | 1.541 (0.883-2.690) | 2.34 | 0.126 |
| rs2227508 | AA | 140 (70) | 166 (66.4%) | Ref | | | AT | 56 (28) | 71 (28.4%) | 1.069 (0.705-1.621) | 0.1 | 0.752 | TT | 4 (2) | 13 (5.2%) | 2.741 (0.874-8.596) | 3.22 | 0.072 | A | 336 (84) | 403 (80.6%) | 1.264 (0.893-1.788) | 1.75 | 0.186 | T | 64 (16) | 97 (19.4%) | TT+AT vs. AA | | | 1.181 (0.791-1.762) | 0.66 | 0.415 | TT vs. AT+AA | | | 2.333 (0.750-7.264) | 3.13 | 0.076 |
| rs2227478 | TT | 84 (42%) | 100 (40%) | Ref | | | CT | 82 (41%) | 115 (46%) | 1.178 (0.785-1.767) | 0.63 | 0.428 | CC | 34 (17%) | 35 (14%) | 0.865 (0.497-1.505) | 0.26 | 0.606 | T | 250 (62.5%) | 315 (63%) | 0.979 (0.746-1.285) | 0.02 | 0.877 | C | 150 (37.5%) | 185 (37%) | CC+CT vs. TT | | | 1.086 (0.744-1.585) | 0.18 | 0.668 | CC vs. CT+TT | | | 0.795 (0.476-1.328) | 0.77 | 0.380 |
| rs2227481 | CC | 126 (63%) | 175 (70%) | Ref | | | CT | 57 (28.5%) | 69 (27.6%) | 0.872 (0.573-1.325) | 0.41 | 0.520 | TT | 17 (8.5%) | 6 (2.4%) | 0.254(0.097-0.663) | 8.9 | 0.002 | C | 309 (77.3%) | 419 (83.8%) | 0.656 (0.470-0.916) | 6.17 | 0.013 | T | 91 (22.7%) | 81 (16.2%) | TT+CT vs. CC | | | 0.730 (0.492-1.083) | 2.46 | 0.116 | TT vs. CT+CC | | | 0.265 (0.102-0.685) | 8.52 | 0.003 |
| rs2227491 | AA | 60 (30%) | 72 (28.8%) | Ref | | | AG | 83 (41.5%) | 123 (49.2%) | 1.235 (0.794-1.920) | 0.88 | 0.348 | GG | 57 (28.5%) | 55 (22%) | 0.804 (0.485-1.332) | 0.72 | 0.396 | A | 203 (50.8%) | 267 (53.4%) | 0.899 (0.691-1.170) | 0.63 | 0.429 | G | 197 (49.2%) | 233 (46.6%) | GG+AG vs. AA | | | 1.060 (0.705-1.593) | 0.08 | 0.781 | GG vs. AG+AA | | | 0.708 (0.461-1.086) | 2.51 | 0.113 |
| rs2227483 | TT | 153 (76.5%) | 204 (81.6%) | Ref | | | AT | 26 (13%) | 13 (5.2%) | 0.375 (0.187-0.754) | 8.05 | 0.004 | AA | 21 (10.5%) | 33 (13.2%) | 1.179 (0.656-2.117) | 0.3 | 0.582 | T | 332 (83%) | 421 (84.2%) | 0.916 (0.643-1.306) | 0.23 | 0.628 | A | 68 (17%) | 79 (15.8%) | AA+AT vs. TT | | | 0.734 (0.465-1.160) | 1.76 | 0.184 | AA vs. AT+TT | | | 1.296 (0.724-2.319) | 0.77 | 0.381 |
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