Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients

Table 2

Genotype distribution and allele frequency of IL-22 SNPs in group I+II+III of parasite density compared to group IV.

SNPs	Genotype/allele distribution	Group I+II+III	Group IV	OR (95% CI)	^2	value
rs976748	TT	86 (95.6%)	150 (93.8%)	Ref
	CT	4 (4.4%)	9 (5.6%)	1.290 (0.386-4.314)	0.17	0.678
	CC	0 (0%)	1 (0.6%)	1.724 (0.069-42.790)	0.57	0.449
	T	176 (97.8%)	309 (96.6%)	1.566 (0.491-4.993)	0.58	0.444
	C	4 (2.2%)	11 (3.4%)
	CC+CT vs. TT			1.433 (0.436-4.709)	0.36	0.551
	CC vs. CT+TT			0.587 (0.024-14.571)	0.56	0.452
rs1179246	CC	28 (31.1%)	57 (35.6%)	Ref
	AC	43 (47.8%)	69 (43.1%)	0.788 (0.436-1.424)	0.62	0.429
	AA	19 (21.1%)	34 (21.3%)	0.879 (0.427-1.808)	0.12	0.725
	C	99 (55%)	183 (57.2%)	0.915 (0.633-1.322)	0.22	0.635
	A	81 (45%)	137 (42.8%)
	AA+AC vs. CC			0.816 (0.470-1.416)	0.52	0.469
	AA vs. AC+CC			1.008 (0.536-1.898)	0	0.979
rs2046068	AA	39 (43.3%)	75 (46.9%)	Ref
	AC	44 (48.9%)	67 (41.9%)	0.792 (0.460-1.362)	0.71	0.398
	CC	7 (7.8%)	18 (11.2%)	1.337 (0.515-3.475)	0.36	0.550
	A	122 (67.8%)	217 (67.8%)	0.998 (0.675-1.476)	0	0.993
	C	58 (32.2%)	103 (32.2%)
	CC+AC vs. AA			0.867 (0.515-1.458)	0.29	0.589
	CC vs. AC+AA			1.503 (0.603-3.749)	0.77	0.379
rs1182844	TT	27 (30%)	63 (39.4%)	Ref
	AT	46 (51.1%)	74 (46.2%)	0.689(0.385-1.234)	1.57	0.209
	AA	17 (18.9%)	23 (14.4%)	0.580 (0.268-1.255)	1.93	0.164
	T	100 (55.6%)	200 (62.5%)	0.750 (0.518-1.087)	2.31	0.128
	A	80 (44.4%)	120 (37.5%)
	AA+AT vs. TT			0.660 (0.380-1.145)	2.2	0.138
	AA vs. AT+TT			0.721 (0.362-1.435)	0.87	0.350
rs2227508	AA	57 (63.3%)	109 (68.1%)	Ref
	AT	26 (28.9%)	45 (28.1%)	0.905 (0.507-1.616)	0.11	0.735
	TT	7 (7.8%)	6 (3.8%)	0.448 (0.144-1.397)	2	0.157
	A	140 (77.8%)	263 (82.2%)	0.759 (0.482-1.194)	1.43	0.231
	T	40 (22.2%)	57 (17.8%)
	TT+AT vs. AA			0.808 (0.470-1.390)	0.59	0.441
	TT vs. AT+AA			0.462 (0.150-1.420)	1.9	0.168
rs2227478	TT	35 (38.9%)	65 (40.6%)	Ref
	CT	38 (42.2%)	77 (48.1%)	1.091 (0.620-1.921)	0.09	0.762
	CC	17 (18.9%)	18 (11.3%)	0.570(0.261-1.244)	2.02	0.155
	T	108 (60%)	207 (64.7%)	0.819 (0.562-1.193)	1.09	0.297
	C	72 (40%)	113 (35.3%)
	CC+CT vs. TT			0.930 (0.548-1.577)	0.07	0.787
	CC vs. CT+TT			0.544 (0.265-1.119)	2.79	0.094
rs2227481	CC	70 (77.8%)	105 (65.6%)	Ref
	CT	16 (17.8%)	53 (33.1%)	2.208 (1.170-4.170)	6.13	0.013
	TT	4 (4.4%)	2 (1.3%)	0.333 (0.059-1.869)	1.71	0.191
	C	156 (86.7%)	263 (82.2%)	1.409 (0.841-2.361)	1.7	0.191
	T	24 (13.3%)	57 (17.8%)
	TT+CT vs. CC			1.833 (1.012-3.322)	4.05	0.044
	TT vs. CT+CC			0.272 (0.0488-1.516)	2.51	0.113
rs2227491	AA	24 (26.7%)	48 (30%)	Ref
	AG	49 (54.4%)	74 (46.2%)	0.755 (0.411-1.388)	0.82	0.365
	GG	17 (18.9%)	38 (23.8%)	1.118 (0526-2.373)	0.08	0.772
	A	97 (53.9%)	170 (53.1%)	1.031 (0.715-1.487)	0.03	0.869
	G	83 (46.1%)	150 (46.9%)
	GG+AG vs. AA			0.848 (0.477-1.510)	0.31	0.576
	GG vs. AG+AA			1.338 (0.704-2.540)	0.79	0.373
rs2227483	TT	73 (81.1%)	131 (81.9%)	Ref
	AT	4 (4.4%)	9 (5.6%)	1.254 (0.373-4.213)	0.13	0.714
	AA	13 (14.5%)	20 (12.5%)	0.857 (0.403-1.823)	0.16	0.689
	T	150 (83.3%)	271 (84.7%)	0.904 (0.550-1.485)	0.16	0.690
	A	30 (16.7%)	49 (15.3%)
	AA+AT vs. TT			0.951 (0.490-1.846)	0.02	0.881
	AA vs. AT+TT			0.846 (0.399-1.794)	0.19	0.662