Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients

Table 3

Genotype distribution and allele frequency of IL-22 SNPs in group 1-5 years of age compared to 6 years and above age group.

SNPs	Genotype/allele distribution	1-5 years	6 years and above	OR (95% CI)	^2	value
rs976748	TT	7 (100%)	229 (94.3%)	Ref
	CT	0 (0%)	13 (5.3%)	0.882 (0.048-16.276)	0.4	0.528
	CC	0 (0%)	1 (0.4%)	0.098 (0.004-2.611)	0.03	0.861
	T	14 (100%)	471 (97%)	0.953 (0.054-16.717)	0.45	1
	C	0 (0%)	15 (3%)
	CC+CT vs. TT			0.948 (0.052-17.423)	0.43	0.513
	CC vs. CT+TT			0.093 (0.004-2.471)	0.03	0.864
rs1179246	CC	2 (28.6%)	85 (35%)	Ref
	AC	5 (71.4%)	107 (44%)	0.504 (0.095-2.660)	0.68	0.410
	AA	0 (0%)	51 (21%)	3.012 (0.142-63.975)	1.19	0.275
	C	9 (64.3%)	277 (57%)	1.358 (0.449-4.112)	0.3	0.586
	A	5 (35.7%)	209 (43%)
	AA+AC vs. CC			0.744 (0.141-3.914)	0.12	0.725
	AA vs. AC+CC			4.013 (0.225-71.433)	1.85	0.174
rs2046068	AA	6 (85.7%)	108 (44.4%)	Ref
	AC	1 (14.3%)	110 (45.3%)	6.111 (0.724-51.609)	3.55	0.059
	CC	0 (0%)	25 (10.3%)	3.055 (0.167-56.007)	1.38	0.240
	A	13 (92.9%)	326 (67%)	6.380 (0.827-49.203)	4.14	0.044
	C	1 (7.1%)	160 (33%)
	CC+AC vs. AA			7.500(0.889-63.242)	4.67	0.030
	CC vs. AC+AA			1.751 (0.097-31.562)	0.8	0.371
rs1182844	TT	3 (42.9%)	87 (35.8%)	Ref
	AT	4 (57.1%)	116 (47.7%)	1.00 (0.218-4.584)	0	1
	AA	0 (0%)	40 (16.5%)	3.240 (0.164-64.205)	1.36	0.242
	T	10 (71.4%)	290 (59.7%)	1.690 (0.523-5.464)	0.78	0.375
	A	4 (28.6%)	196 (40.3%)
	AA+AT vs. TT			1.345 (0.294-6.147)	0.15	0.701
	AA vs. AT+TT			2.985 (0.167-53.317)	1.37	0.241
rs2227508	AA	6 (85.7%)	160 (65.8%)	Ref
	AT	1 (14.3%)	70 (28.8%)	2.625 (0.310-22.212)	0.84	0.358
	TT	0 (0%)	13 (5.4%)	1.093 (0.058-20.469)	0.49	0.485
	A	13 (92.9%)	390 (80.2%)	3.200 (0.414-24.762)	1.38	0.323
	T	1 (7.1%)	96 (19.8%)
	TT+AT vs. AA			3.112 (0.369-26.284)	1.2	0.272
	TT vs. AT+AA			0.879 (0.047-16.206)	0.4	0.529
rs2227478	TT	5 (71.4%)	95 (39.1%)	Ref
	CT	2 (28.6%)	113 (46.5%)	2.974 (0.564-15.677)	1.81	0.179
	CC	0 (0%)	35 (14.4%)	4.089 (0.220-75.860)	1.82	0.177
	T	12 (85.7%)	303 (62.3%)	3.624 (0.802-16.374)	3.19	0.074
	C	2 (14.3%)	183 (37.7%)
	CC+CT vs. TT			3.895 (0.741-20.482)	2.96	0.085
	CC vs. CT+TT			2.554 (0.143-45.516)	1.17	0.278
rs2227481	CC	6 (85.7%)	169 (69.5%)	Ref
	CT	1 (14.3%)	68 (28%)	2.414 (0.285-20.430)	0.7	0.404
	TT	0 (0%)	6 (2.5%)	0.499 (0.025-9.827)	0.21	0.644
	C	13 (92.9%)	406 (83.5%)	2.562 (0.330-19.859)	0.87	0.710
	T	1 (7.1%)	80 (16.5%)
	TT+CT vs. CC			2.627 (0.311-22.209)	0.85	0.357
	TT vs. CT+CC			0.411 (0.0211-7.977)	0.18	0.673
rs2227491	AA	3 (42.9%)	72 (29.6%)	Ref
	AG	4 (57.1%)	119 (49%)	1.240 (0.270-5.698)	0.08	0.782
	GG	0 (0%)	52 (21.4%)	5.069 (0.256-100.237)	2.13	0.144
	A	10 (71.4%)	263 (54.1%)	2.120 (0.656-6.852)	1.65	0.199
	G	4 (28.6%)	223 (45.9%)
	GG+AG vs. AA			1.781 (0.389-8.161)	0.57	0.451
	GG vs. AG+AA			4.112 (0.231-73.184)	1.89	0.169
rs2227483	TT	5 (71.4%)	199 (81.9%)	Ref
	AT	0 (0%)	13 (5.3%)	0.744 (0.039-14.180)	0.33	0.567
	AA	2 (28.6%)	31 (12.8%)	0.389 (0.072-2.096)	1.29	0.255
	T	10 (71.4%)	411 (84.6%)	0.456 (0.139-1.493)	1.77	0.252
	A	4 (28.6%)	75 (15.4%)
	AA+AT vs. TT			0.553 (0.104-2.942)	0.5	0.481
	AA vs. AT+TT			0.365 (0.068-1.966)	1.49	0.222