Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients

Table 4

Genotype distribution and allele frequency of IL-22 SNPs in group 1-9 years of age compared to 10 years and above age group.

SNPs	Genotype/allele distribution	1-9 years	10 years and above	OR (95% CI)	^2	value
rs976748	TT	15 (83.3%)	221 (95.3%)	Ref
	CT	3 (16.7%)	10 (4.3%)	0.226 (0.056-0.910)	5.14	0.023
	CC	0 (0%)	1 (0.4%)	0.210 (0.008-5.370)	0.07	0.794
	T	33 (91.7%)	452 (97.4%)	0.292 (0.079-1.086)	3.79	0.085
	C	3 (8.3%)	12 (2.6%)
	CC+CT vs. TT			0.249 (0.063-0.989)	4.49	0.034
	CC vs. CT+TT			0.240 (0.009-6.094)	0.08	0.780
rs1179246	CC	5 (27.8%)	80 (34.5%)	Ref
	AC	8 (44.4%)	104 (44.8%)	0.812 (0.256-2.578)	0.12	0.724
	AA	5 (27.8%)	48 (20.7%)	0.600 (0.165-2.180)	0.61	0.433
	C	18 (50%)	264 (56.9%)	0.758 (0.384-1.493)	0.65	0.421
	A	18 (50%)	200 (43.1%)
	AA+AC vs. CC			0.731 (0.252-2.123)	0.33	0.562
	AA vs. AC+CC			10.678 (0.231-1.996)	0.5	0.478
rs2046068	AA	12 (66.7%)	102 (44%)	Ref
	AC	6 (33.3%)	105 (45.3%)	2.059 (0.745-5.693)	2	0.156
	CC	0 (0%)	25 (10.7%)	6.220 (0.356-108.579)	2.88	0.089
	A	30 (83.3%)	309 (66.6%)	2.508 (1.022-6.154)	4.29	0.038
	C	6 (16.7%)	155 (33.4%)
	CC+AC vs. AA			2.549(0.925-7.024)	3.47	0.062
	CC vs. AC+AA			4.547 (0.266-77.748)	2.16	0.142
rs1182844	TT	7 (38.9%)	83 (35.8%)	Ref
	AT	11 (61.1%)	109 (41%)	0.836 (0.311-2.248)	0.13	0.721
	AA	0 (0%)	40 (17.2%)	7.275 (0.405-130.544)	3.29	0.069
	T	25 (69.4%)	275 (59.3%)	1.562 (0.751-3.251)	1.44	0.229
	A	11 (30.6%)	189 (40.7%)
	AA+AT vs. TT			1.142 (0.427-3.059)	0.07	0.790
	AA vs. AT+TT			7.784 (0.459-131.835)	3.69	0.054
rs2227508	AA	14 (77.8%)	152 (65.5%)	Ref
	AT	4 (22.2%)	67 (28.9%)	1.543 (0.490-4.861)	0.56	0.456
	TT	0 (0%)	13 (5.6%)	2.567 (0.145-45.441)	1.19	0.275
	A	32 (88.9%)	371 (80%)	2.005 (0.692-5.811)	1.7	0.191
	T	4 (11.1%)	93 (20%)
	TT+AT vs. AA			1.842 (0.587-5.781)	1.13	0.288
	TT vs. AT+AA			2.276 (0.130-39.829)	1.06	0.302
rs2227478	TT	11 (61.1%)	89 (38.4%)	Ref
	CT	4 (22.2%)	111 (47.8%)	3.430 (1.056-11.138)	4.66	0.030
	CC	3 (16.7%)	32 (13.8%)	1.318 (0.346-5.030)	0.16	0.685
	T	26 (72.2%)	289 (62.3%)	1.574 (0.741-3.343)	1.42	0.234
	C	10 (27.8%)	175 (37.7%)
	CC+CT vs. TT			2.525 (0.944-6.754)	3.6	0.057
	CC vs. CT+TT			0.800 (0.219-2.919)	0.11	0.735
rs2227481	CC	13 (72.2%)	162 (69.8%)	Ref
	CT	4 (22.2%)	65 (28%)	1.304 (0.410-4.147)	0.2	0.652
	TT	1 (5.6%)	5 (2.2%)	0.401 (0.044-3.695)	0.69	0.404
	C	30 (83.3%)	389 (83.8%)	0.964(0.388-2.397)	0.01	0.937
	T	6 (16.7%)	75 (16.2%)
	TT+CT vs. CC			1.123 (0.386-3.271)	0.05	0.830
	TT vs. CT+CC			0.374 (0.041-3.389)	0.82	0.363
rs2227491	AA	5 (27.7%)	71 (30.6%)	Ref
	AG	12 (66.7%)	111 (47.8%)	0.651 (0.220-1.928)	0.61	0.435
	GG	1 (5.6%)	50 (21.6%)	3.52 (0.399-31.065)	1.45	0.229
	A	22 (61.1%)	253 (54.5%)	1.311 (0.654-2.625)	0.59	0.444
	G	14 (38.9%)	211 (45.5%)
	GG+AG vs. AA			0.872(0.300-2.539)	0.06	0.801
	GG vs. AG+AA			4.670 (0.607-35.952)	2.63	0.104
rs2227483	TT	12 (66.7%)	192 (82.8%)	Ref
	AT	1 (5.6%)	12 (5.2%)	0.750 (0.090-6.259)	0.07	0.789
	AA	5 (27.7%)	28 (12%)	0.350 (0.115-1.068)	3.67	0.055
	T	25 (69.4%)	396 (85.3%)	0.390 (0.184-0.830)	6.35	0.011
	A	11 (30.6%)	68 (14.7%)
	AA+AT vs. TT			0.417 (0.148-1.176)	2.88	0.089
	AA vs. AT+TT			0.357 (0.118-1.077)	3.6	0.057