Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients

Table 5

Genotype distribution and allele frequency of IL-22 SNPs in group 1-9 years of age compared to 41 years and above age group.

SNPs	Genotype/allele distribution	1-9 years	41 years and above	OR (95% CI)	^2	value
rs976748	TT	15 (83.3%)	49 (90.7%)	Ref
	CT	3 (16.7%)	5 (9.3%)	0.510 (0.109-2.389)	0.75	0.386
	CC	0 (0%)	0 (0%)	0.313 (0.006-16.446)	Nan	1
	T	33 (91.7%)	103 (95.4%)	0.534 (0.121-2.355)	0.71	0.412
	C	3 (8.3%)	5 (4.6%)
	CC+CT vs. TT			0.510 (0.109-2.389)	0.75	0.386
	CC vs. CT+TT			0.339 (0.007-17.723)	Nan	1
rs1179246	CC	5 (27.8%)	25 (46.3%)	Ref
	AC	8 (44.4%)	16 (29.6%)	0.400 (0.111-1.441)	2.03	0.154
	AA	5 (27.8%)	13 (24.1%)	0.520 (0.127-2.128)	0.84	0.358
	C	18 (50%)	66 (61.1%)	0.636 (0.298-1.360)	1.37	0.241
	A	18 (50%)	42 (38.9%)
	AA+AC vs. CC			0.446 (0.140-1.426)	1.9	0.167
	AA vs. AC+CC			0.824 (0.247-2.752)	0.1	0.753
rs2046068	AA	12 (66.7%)	25 (46.3%)	Ref
	AC	6 (33.3%)	21 (38.9%)	1.680 (0.538-5.247)	0.8	0.369
	CC	0 (0%)	8 (14.8%)	8.333 (0.444-156.275)	3.54	0.059
	A	30 (83.3%)	71 (65.7%)	2.606 (0.995-6.821)	3.99	0.045
	C	6 (16.7%)	37 (34.3%)
	CC+AC vs. AA			2.320(0.760-7.085)	2.24	0.134
	CC vs. AC+AA			6.763 (0.371-123.24)	3	0.083
rs1182844	TT	7 (38.9%)	20 (37%)	Ref
	AT	11 (61.1%)	22 (40.7%)	0.700 (0.227-2.155)	0.39	0.533
	AA	0 (0%)	12 (22.2%)	9.146 (0.480-174.374)	3.79	0.051
	T	25 (69.4%)	62 (57.4%)	1.686 (0.754-3.772)	1.64	0.200
	A	11 (30.6%)	46 (42.6%)
	AA+AT vs. TT			1.082 (0.361-3.240)	0.02	0.888
	AA vs. AT+TT			10.882 (0.612-193.665)	4.8	0.028
rs2227508	AA	14 (77.8%)	36 (66.7%)	Ref
	AT	4 (22.2%)	14 (25.9%)	1.361 (0.382-4.852)	0.23	0.633
	TT	0 (0%)	4 (7.4%)	3.757 (0.181-70.702)	1.51	0.218
	A	32 (88.9%)	86 (79.6%)	2.047 (0.654-6.399)	1.56	0.211
	T	4 (11.1%)	22 (20.4%)
	TT+AT vs. AA			1.750 (0.503-6.089)	0.79	0.375
	TT vs. AT+AA			3.297 (0.169-64.262)	1.41	0.234
rs2227478	TT	11 (61.1%)	24 (44.4%)	Ref
	CT	4 (22.2%)	20 (37%)	2.292 (0.631-8.317)	1.64	0.200
	CC	3 (16.7%)	10 (18.5%)	1.528 (0.350-6.674)	0.32	0.571
	T	26 (72.2%)	68 (63%)	1.529(0.669-3.498)	1.02	0.312
	C	10 (27.8%)	40 (37%)
	CC+CT vs. TT			1.964 (0.661-5.837)	1.5	0.220
	CC vs. CT+TT			1.136 (0.276-4.688)	0.03	0.859
rs2227481	CC	13 (72.2%)	38 (70.4%)	Ref
	CT	4 (22.2%)	13 (24.1%)	1.112 (0.307-4.021)	0.03	0.871
	TT	1 (5.6%)	3 (5.5%)	1.026 (0.098-10.752)	0	0.982
	C	30 (83.3%)	89 (82.4%)	1.067 (0.390-2.921)	0.02	0.898
	T	6 (16.7%)	19 (17.6%)
	TT+CT vs. CC			1.095 (0.335-3.582)	0.02	0.881
	TT vs. CT+CC			1.00 (0.097-10.265)	0	1
rs2227491	AA	5 (27.7%)	20 (37%)	Ref
	AG	12 (66.7%)	22 (40.7%)	0.458 (0.137-1.531)	1.64	0.199
	GG	1 (5.6%)	12 (22.2%)	3 (0.312-28.841)	0.97	0.336
	A	22 (61.1%)	62 (57.4%)	1.166 (0.539-2.521)	0.15	0.696
	G	14 (38.9%)	46 (42.6%)
	GG+AG vs. AA			0.6654 (0.203-2.107)	0.51	0.474
	GG vs. AG+AA			4.857 (0.585-40.32)	2.53	0.111
rs2227483	TT	12 (66.7%)	46 (85.2%)	Ref
	AT	1 (5.6%)	1 (1.9%)	0.261 (0.015-4.481)	0.98	0.322
	AA	5 (27.7%)	7 (12.9%)	0.365(0.098-1.356)	2.38	0.122
	T	25 (69.4%)	93 (86.1%)	0.367 (0.150-0.897)	5.07	0.024
	A	11 (30.6%)	15 (13.9%)
	AA+AT vs. TT			0.348 (0.101-1.195)	2.96	0.085
	AA vs. AT+TT			0.387 (0.105-1.423)	2.13	0.144