Research Article
Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients
Table 5
Genotype distribution and allele frequency of IL-22 SNPs in group 1-9 years of age compared to 41 years and above age group.
| SNPs | Genotype/allele distribution | 1-9 years | 41 years and above | OR (95% CI) | 2 | value |
| rs976748 | TT | 15 (83.3%) | 49 (90.7%) | Ref | | | CT | 3 (16.7%) | 5 (9.3%) | 0.510 (0.109-2.389) | 0.75 | 0.386 | CC | 0 (0%) | 0 (0%) | 0.313 (0.006-16.446) | Nan | 1 | T | 33 (91.7%) | 103 (95.4%) | 0.534 (0.121-2.355) | 0.71 | 0.412 | C | 3 (8.3%) | 5 (4.6%) | CC+CT vs. TT | | | 0.510 (0.109-2.389) | 0.75 | 0.386 | CC vs. CT+TT | | | 0.339 (0.007-17.723) | Nan | 1 |
| rs1179246 | CC | 5 (27.8%) | 25 (46.3%) | Ref | | | AC | 8 (44.4%) | 16 (29.6%) | 0.400 (0.111-1.441) | 2.03 | 0.154 | AA | 5 (27.8%) | 13 (24.1%) | 0.520 (0.127-2.128) | 0.84 | 0.358 | C | 18 (50%) | 66 (61.1%) | 0.636 (0.298-1.360) | 1.37 | 0.241 | A | 18 (50%) | 42 (38.9%) | AA+AC vs. CC | | | 0.446 (0.140-1.426) | 1.9 | 0.167 | AA vs. AC+CC | | | 0.824 (0.247-2.752) | 0.1 | 0.753 |
| rs2046068 | AA | 12 (66.7%) | 25 (46.3%) | Ref | | | AC | 6 (33.3%) | 21 (38.9%) | 1.680 (0.538-5.247) | 0.8 | 0.369 | CC | 0 (0%) | 8 (14.8%) | 8.333 (0.444-156.275) | 3.54 | 0.059 | A | 30 (83.3%) | 71 (65.7%) | 2.606 (0.995-6.821) | 3.99 | 0.045 | C | 6 (16.7%) | 37 (34.3%) | CC+AC vs. AA | | | 2.320(0.760-7.085) | 2.24 | 0.134 | CC vs. AC+AA | | | 6.763 (0.371-123.24) | 3 | 0.083 |
| rs1182844 | TT | 7 (38.9%) | 20 (37%) | Ref | | | AT | 11 (61.1%) | 22 (40.7%) | 0.700 (0.227-2.155) | 0.39 | 0.533 | AA | 0 (0%) | 12 (22.2%) | 9.146 (0.480-174.374) | 3.79 | 0.051 | T | 25 (69.4%) | 62 (57.4%) | 1.686 (0.754-3.772) | 1.64 | 0.200 | A | 11 (30.6%) | 46 (42.6%) | AA+AT vs. TT | | | 1.082 (0.361-3.240) | 0.02 | 0.888 | AA vs. AT+TT | | | 10.882 (0.612-193.665) | 4.8 | 0.028 |
| rs2227508 | AA | 14 (77.8%) | 36 (66.7%) | Ref | | | AT | 4 (22.2%) | 14 (25.9%) | 1.361 (0.382-4.852) | 0.23 | 0.633 | TT | 0 (0%) | 4 (7.4%) | 3.757 (0.181-70.702) | 1.51 | 0.218 | A | 32 (88.9%) | 86 (79.6%) | 2.047 (0.654-6.399) | 1.56 | 0.211 | T | 4 (11.1%) | 22 (20.4%) | TT+AT vs. AA | | | 1.750 (0.503-6.089) | 0.79 | 0.375 | TT vs. AT+AA | | | 3.297 (0.169-64.262) | 1.41 | 0.234 |
| rs2227478 | TT | 11 (61.1%) | 24 (44.4%) | Ref | | | CT | 4 (22.2%) | 20 (37%) | 2.292 (0.631-8.317) | 1.64 | 0.200 | CC | 3 (16.7%) | 10 (18.5%) | 1.528 (0.350-6.674) | 0.32 | 0.571 | T | 26 (72.2%) | 68 (63%) | 1.529(0.669-3.498) | 1.02 | 0.312 | C | 10 (27.8%) | 40 (37%) | CC+CT vs. TT | | | 1.964 (0.661-5.837) | 1.5 | 0.220 | CC vs. CT+TT | | | 1.136 (0.276-4.688) | 0.03 | 0.859 |
| rs2227481 | CC | 13 (72.2%) | 38 (70.4%) | Ref | | | CT | 4 (22.2%) | 13 (24.1%) | 1.112 (0.307-4.021) | 0.03 | 0.871 | TT | 1 (5.6%) | 3 (5.5%) | 1.026 (0.098-10.752) | 0 | 0.982 | C | 30 (83.3%) | 89 (82.4%) | 1.067 (0.390-2.921) | 0.02 | 0.898 | T | 6 (16.7%) | 19 (17.6%) | TT+CT vs. CC | | | 1.095 (0.335-3.582) | 0.02 | 0.881 | TT vs. CT+CC | | | 1.00 (0.097-10.265) | 0 | 1 |
| rs2227491 | AA | 5 (27.7%) | 20 (37%) | Ref | | | AG | 12 (66.7%) | 22 (40.7%) | 0.458 (0.137-1.531) | 1.64 | 0.199 | GG | 1 (5.6%) | 12 (22.2%) | 3 (0.312-28.841) | 0.97 | 0.336 | A | 22 (61.1%) | 62 (57.4%) | 1.166 (0.539-2.521) | 0.15 | 0.696 | G | 14 (38.9%) | 46 (42.6%) | GG+AG vs. AA | | | 0.6654 (0.203-2.107) | 0.51 | 0.474 | GG vs. AG+AA | | | 4.857 (0.585-40.32) | 2.53 | 0.111 |
| rs2227483 | TT | 12 (66.7%) | 46 (85.2%) | Ref | | | AT | 1 (5.6%) | 1 (1.9%) | 0.261 (0.015-4.481) | 0.98 | 0.322 | AA | 5 (27.7%) | 7 (12.9%) | 0.365(0.098-1.356) | 2.38 | 0.122 | T | 25 (69.4%) | 93 (86.1%) | 0.367 (0.150-0.897) | 5.07 | 0.024 | A | 11 (30.6%) | 15 (13.9%) | AA+AT vs. TT | | | 0.348 (0.101-1.195) | 2.96 | 0.085 | AA vs. AT+TT | | | 0.387 (0.105-1.423) | 2.13 | 0.144 |
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