Baicalein Restores the Balance of Th17/Treg Cells via Aryl Hydrocarbon Receptor to Attenuate Colitis

Figure 2

Baicalein ameliorated disease activity in mice with DSS-induced colitis. Mice were orally administrated of 3% DSS for seven days and followed by sterile distilled water alone for another three days. Baicalein (10, 20, and 40 mg/kg) and mesalazine (600 mg/kg) were orally administered daily for 10 consecutive days. Mice were treated by oral administration of baicalein (40 mg/kg) and intraperitoneal injection of CH223191 (10 mg/kg) for 10 consecutive days and intraperitoneal injection of TCDD (25 μg/kg) on day 1. On the 11^th day, mice were sacrificed, and colons were collected. (a) Bodyweight changes were evaluated in each group. (b) Disease activity index (DAI) scores were evaluated in each group. (c, d) The colon lengths were evaluated in each group. (e, f) The spleen and thymus index were calculated. #, ^##, and ^### vs. the control group. , , and vs. the model group. (g, h) The histological changes were detected by using H&E staining, and histological activity index (HAI) was evaluated in each group (100x original magnification). Results were expressed as #, ^##, and ^### vs. the control group. , , and vs. the model group.

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