Age-Related Differences in the Association between Plasma High-Sensitivity C-Reactive Protein and Noncalcified or Mixed Coronary Atherosclerotic Plaques
Table 1
Baseline characteristics of the study population according to the type of plaques.
Variables
CR ()
CP ()
NCP/MP ()
Age (years)
a
<0.001
BMI (kg/m2)
0.026
Male, (%)
89 (44.7%)
204 (52.6%)
243 (66.8%)a
<0.001
Hypertension, (%)
92 (46.2%)
298 (76.8%)
256 (70.3%)
<0.001
Diabetes, (%)
21 (10.6%)
96 (24.7%)
107 (29.4%)
<0.001
Dyslipidemia, (%)
77 (38.7%)
300 (77.3%)
299 (82.1%)
<0.001
Smoking, (%)
39 (19.6%)
95 (24.5%)
126 (34.6%)a
<0.001
Alcohol consumption, (%)
41 (20.6%)
99 (25.5%)
119 (32.7%)b
0.005
History of CAD, (%)
27 (13.6%)
39 (10.1%)
41 (11.3%)
0.443
Biochemical parameters
TC (mmol/L)
0.002
TG (mmol/L)
1.45 (1.02, 2.08)
1.47 (1.08, 2.05)
1.55 (1.15, 2.22)
0.113
HDL-C (mmol/L)
a
<0.001
LDL-C (mmol/L)
<0.001
hsCRP (mg/L)
1.52 (0.79, 2.71)
1.63 (0.89, 3.23)
1.93 (0.97, 3.90)
0.016
Medications, (%)
Statins
63 (31.7%)
261 (67.3%)
267 (73.4%)
<0.001
Aspirin
73 (36.7%)
277 (71.4%)
269 (73.9%)
<0.001
Calcium antagonists
29 (14.6%)
157 (40.5%)
117 (32.1%)b
<0.001
ARB/ACEI
28 (14.1%)
160 (41.2%)
156 (42.9%)
<0.001
Beta-blockers
54 (27.1%)
206 (53.1%)
181 (49.7%)
<0.001
Diuretics
18 (9.0%)
76 (19.6%)
63 (17.3%)
0.004
Abbreviations: CR—control; CP—calcified plaque; NCP—noncalcified plaque; MP—mixed plaque; BMI—body mass index; CAD—coronary artery disease; TC—total cholesterol; TG—triglycerides; HDL-C—high-density lipoprotein cholesterol; LDL-C——low-density lipoprotein cholesterol; hsCRP—high-sensitivity C-reactive protein; ARB—angiotensin II receptor blockers; ACEI—angiotensin-converting enzyme inhibitors. a for NCP/MP vs. CP. b for NCP/MP vs. CP.
