Age-Related Differences in the Association between Plasma High-Sensitivity C-Reactive Protein and Noncalcified or Mixed Coronary Atherosclerotic Plaques
Table 2
Demographic and clinical characteristics of the study subjects according to age-specific type of plaques.
Variables
CR ()
CP ()
NCP/MP ()
CR ()
CP ()
NCP/MP ()
Age (years)
a
<0.001
<0.001
BMI (kg/m2)
0.009
b
0.070
Male, (%)
78 (48.4%)
110 (69.2%)
154 (74.4%)
<0.001
11 (28.9%)
94 (41.0%)
89 (56.7%)
0.001
Hypertension, (%)
74 (46.0%)
113 (71.1%)
140 (67.6%)
<0.001
18 (47.4%)
185 (80.8%)
116 (73.9%)
<0.001
Diabetes, (%)
15 (9.3%)
34 (21.4%)
53 (25.6%)
<0.001
6 (15.8%)
62 (27.1%)
54 (34.4%)
0.053
Dyslipidemia, (%)
61 (37.9%)
120 (75.5%)
166 (80.2%)
<0.001
16 (42.1%)
180 (78.6%)
133 (84.7%)
<0.001
Smoking, (%)
37 (23.0%)
62 (39.0%)
88 (42.5%)
<0.001
2 (5.3%)
33 (14.4%)
38 (24.2%)c
0.005
Alcohol consumption, (%)
41 (25.5%)
67 (42.1%)
93 (44.9%)
<0.001
0 (0.0%)
32 (14.0%)
26 (16.6%)
0.028
History of CAD, (%)
24 (14.9%)
23 (14.5%)
28 (13.5%)
0.927
3 (7.9%)
16 (7.0%)
13 (8.3%)
0.891
Biochemical parameters
TC (mmol/L)
0.005
0.729
TG (mmol/L)
1.46 (1.05, 2.14)
1.66 (1.13, 2.29)
1.62 (1.21, 2.41)
0.118
1.43 (0.95, 1.87)
1.39 (1.03, 1.83)
1.41 (1.05, 2.13)
0.380
HDL-C (mmol/L)
<0.001
0.001
LDL-C (mmol/L)
0.008
0.250
hsCRP (mg/L)
1.51 (0.73, 2.72)
1.68 (0.77, 3.40)
1.82 (0.81, 3.34)
0.279
1.84 (1.10, 2.71)
1.62 (0.93, 3.11)
2.26 (1.26, 4.63)b
0.003
Medications, (%)
Statins
52 (32.3%)
100 (62.9%)
150 (72.5%)
<0.001
11 (28.9%)
161 (70.3%)
117 (74.5%)
<0.001
Aspirin
60 (37.3%)
105 (66.0%)
145 (70.0%)
<0.001
13 (34.2%)
172 (75.1%)
124 (79.0%)
<0.001
Calcium antagonists
20 (12.4%)
55 (34.6%)
61 (29.5%)
<0.001
9 (23.7%)
102 (44.5%)
56 (35.7%)
0.025
ARB/ACEI
26 (16.1%)
58 (36.5%)
86 (41.5%)
<0.001
2 (5.3%)
102 (44.5%)
70 (44.6%)
<0.001
Beta-blockers
44 (27.3%)
75 (47.2%)
93 (44.9%)
<0.001
10 (26.3%)
131 (57.2%)
88 (56.1%)
0.002
Abbreviations: CR—control; CP—calcified plaque; NCP—noncalcified plaque; MP—mixed plaque; BMI—body mass index; CAD—coronary artery disease; TC—total cholesterol; TG—triglycerides; HDL-C—high-density lipoprotein cholesterol; LDL-C—low-density lipoprotein cholesterol; hsCRP—high-sensitivity C-reactive protein; ARB—angiotensin II receptor blockers; ACEI—angiotensin-converting enzyme inhibitors. a for NCP/MP vs. CP in subjects with years. b for NCP/MP vs. CP in subjects with years. c for NCP/MP vs. CP in subjects with years.
