Increased Serum Interleukin-2 Levels Are Associated with Abnormal Peripheral Blood Natural Killer Cell Levels in Patients with Active Rheumatoid Arthritis
Table 4
Peripheral blood lymphocytes and CD4+ T cells of RA patients in each disease activity group.
(a)
Total T
Total T%
Total B
Total B%
Remission group (A) ()
1664.60 1296.80-2078.74
74.88 66.89-76.95
237.98 176.73-393.59
11.00 8.56-14.13
Low disease activity group (B) ()
1293.00 914.85-1707.04
73.89 65.45-78.00
178.11 136.50-282.50
11.00 8.63-14.12
Moderate-high disease activity group (C) ()
1223.00 651.00-1698.00
72.16 68.72-76.77
159.60 103.36-273.15
10.01 7.83-15.00
, A vs. B
0.017
0.986
0.029
0.940
, A vs. C
0.003
0.816
0.001
0.615
, B vs. C
0.493
0.761
0.281
0.683
(b)
NK
NK%
CD4+
CD8+
Th1
Remission group (A) ()
237.00 139.00-301.00
12.51 7.50-15.99
848.64 671.28-1182.02
851.87 456.51-876.82
158.23 110.04-267.17
Low disease activity group (B) ()
218.50 144.50-299.75
12.20 7.60-18.75
633.74 497.18-953.50
472.17 304.34-713.09
119.72 62.96-199.36
Moderate-high disease activity group (C) ()
283.00 217.00-370.00
18.46 15.26-23.47
765.80 434.00-981.00
373.97 214.12-505.40
96.92 68.97-184.99
, A vs. B
0.808
0.669
0.018
0.026
0.018
, A vs. C
0.046
<0.001
0.118
<0.001
0.011
, B vs. C
0.020
0.001
0.817
0.090
0.812
(c)
Th2
Th17
Treg
Th1/Th2
Th17/Treg
Remission group (A) ()
7.50 4.86-11.17
11.31 7.41-14.56
34.76 27.43-44.60
26.58 18.02-39.57
0.29 0.23-0.34
Low disease activity group (B) ()
5.34 3.41-8.40
7.52 4.79-10.92
27.92 16.34-38.28
20.56 14.92-28.54
0.29 0.20-0.44
Moderate-high disease activity group (C) ()
5.51 3.41-8.72
7.71 5.23-13.59
25.12 13.06-30.58
18.86 14.50-28.30
0.40 0.28-0.62
, A vs. B
0.042
0.012
0.005
0.050
0.668
, A vs. C
0.099
0.097
<0.001
0.031
0.003
, B vs. C
0.982
0.406
0.108
0.707
0.010
Results are expressed as the median and 25th and 75th percentiles. Statistics: Wilcoxon’s rank sum test. Abbreviations: RA: rheumatoid arthritis; Total T: total T cells; Total T%: T lymphocyte percentage; Total B: total B cells; Total B%: B lymphocyte percentage; NK: natural killer T cells; NK%: percentage of NK cells; CD4+: CD4+ T cells; CD8+: CD8+ T cells; Th1: T helper 1 cells; Th2: T helper 2 cells; Th17: T helper 17 cells; Treg: regulatory T cells; Th1/Th2: T helper 1 cell/T helper 2 cell ratio; Th17/Treg: T helper 17 cell/regulatory T cell ratio.
