Mediators of Inflammation / 2020 / Article / Tab 4

Research Article

Increased Serum Interleukin-2 Levels Are Associated with Abnormal Peripheral Blood Natural Killer Cell Levels in Patients with Active Rheumatoid Arthritis

Table 4

Peripheral blood lymphocytes and CD4+ T cells of RA patients in each disease activity group.
(a)

Total TTotal T%Total BTotal B%

Remission group (A) ()1664.60
1296.80-2078.74
74.88
66.89-76.95
237.98
176.73-393.59
11.00
8.56-14.13
Low disease activity group (B) ()1293.00
914.85-1707.04
73.89
65.45-78.00
178.11
136.50-282.50
11.00
8.63-14.12
Moderate-high disease activity group (C) ()1223.00
651.00-1698.00
72.16
68.72-76.77
159.60
103.36-273.15
10.01
7.83-15.00
, A vs. B0.0170.9860.0290.940
, A vs. C0.0030.8160.0010.615
, B vs. C0.4930.7610.2810.683

(b)

NKNK%CD4+CD8+Th1

Remission group (A) ()237.00
139.00-301.00
12.51
7.50-15.99
848.64
671.28-1182.02
851.87
456.51-876.82
158.23
110.04-267.17
Low disease activity group (B) ()218.50
144.50-299.75
12.20
7.60-18.75
633.74
497.18-953.50
472.17
304.34-713.09
119.72
62.96-199.36
Moderate-high disease activity group (C) ()283.00
217.00-370.00
18.46
15.26-23.47
765.80
434.00-981.00
373.97
214.12-505.40
96.92
68.97-184.99
, A vs. B0.8080.6690.0180.0260.018
, A vs. C0.046<0.0010.118<0.0010.011
, B vs. C0.0200.0010.8170.0900.812

(c)

Th2Th17TregTh1/Th2Th17/Treg

Remission group (A) ()7.50
4.86-11.17
11.31
7.41-14.56
34.76
27.43-44.60
26.58
18.02-39.57
0.29
0.23-0.34
Low disease activity group (B) ()5.34
3.41-8.40
7.52
4.79-10.92
27.92
16.34-38.28
20.56
14.92-28.54
0.29
0.20-0.44
Moderate-high disease activity group (C) ()5.51
3.41-8.72
7.71
5.23-13.59
25.12
13.06-30.58
18.86
14.50-28.30
0.40
0.28-0.62
, A vs. B0.0420.0120.0050.0500.668
, A vs. C0.0990.097<0.0010.0310.003
, B vs. C0.9820.4060.1080.7070.010

Results are expressed as the median and 25th and 75th percentiles. Statistics: Wilcoxon’s rank sum test. Abbreviations: RA: rheumatoid arthritis; Total T: total T cells; Total T%: T lymphocyte percentage; Total B: total B cells; Total B%: B lymphocyte percentage; NK: natural killer T cells; NK%: percentage of NK cells; CD4+: CD4+ T cells; CD8+: CD8+ T cells; Th1: T helper 1 cells; Th2: T helper 2 cells; Th17: T helper 17 cells; Treg: regulatory T cells; Th1/Th2: T helper 1 cell/T helper 2 cell ratio; Th17/Treg: T helper 17 cell/regulatory T cell ratio.

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