Assessing the Effects of Parthenolide on Inflammation, Bone Loss, and Glial Cells within a Collagen Antibody-Induced Arthritis Mouse Model

Figure 2

Assessment of bone volume (BV) and paw volume (PV) in mouse paws by high-resolution micro-CT: (a) three-dimensional micro-CT models of the radiocarpal joint and surrounding soft tissue (indicated in red) in the right paw. White arrows represent soft tissue volume for control. Yellow arrows represent the soft tissue volume for each disease group and highlight the difference in soft tissue and volume observed. Mean BV in the radiocarpal joint and hind paw (b and c, respectively) and mean PV in the radiocarpal joint and hind paw (d and e, respectively) expressed in mm³, as assessed by micro-CT analysis at day 11. Error bars represent SEM ( paws per control, CAIA+PAR 1 mg/kg, and CAIA+PAR 4 mg/kg; paws per CAIA; , , compared to control; ^## compared to CAIA).

(a)

(b) Radiocarpal joint

(c) Hind paw

(d) Radiocarpal joint

(e) Hind paw