Assessing the Effects of Parthenolide on Inflammation, Bone Loss, and Glial Cells within a Collagen Antibody-Induced Arthritis Mouse Model

Figure 6

Histological assessment of GFAP-positive cells in the lumbar spinal cord region, PAG, and RVM: (a) Representative GFAP-stained image of the spinal cord (40x magnification; scale bars represent 50 μm); (b) representative GFAP-stained image of the PAG (40x magnification; scale bars represent 50 μm); (c) area under the curve analysis of the average number of GFAP-positive cells in serial sections within the lumbar region of the spinal cord. Average number of GFAP-positive cells in the PAG and RVM of the brain (d and e, respectively). Error bars represent SEM ( animals per control, CAIA+PAR 1 mg/kg, and CAIA+PAR 4 mg/kg, animals per CAIA), , , .

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