Protein Kinase A Is Involved in Neuropathic Pain by Activating the p38MAPK Pathway to Mediate Spinal Cord Cell Apoptosis

Figure 5

SNI causes neuropathic pain and increases the expression of PKA and p-p38 in the spinal cord. (a, b) SNI ipsilateral PWT (a) and contralateral PWT (b) (). versus Sham group. (c–e) Western blots and quantification of PKA and p-p38 expression in the spinal cord (). , , versus Sham group. (f) Immunofluorescence images showing PKA expression (green) in the dorsal horn of the spinal cord. (g) Immunofluorescence images showing the distribution of PKA in the cells of the dorsal horn of the spinal cord. PKA is green, NeuN, GFAP, and Iba-1 are red.

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