Research Progress on NK Cell Receptors and Their Signaling Pathways

Figure 3

NKG2D signaling pathways. After DAP10 associates with NKG2D, it can bind to PI3K and the Grb2-Vav-1-SOS1 complex. The Grb2-Vav-1-SOS1 complex activates SLP76, PLCγ2, and Rac1. Rac1 can activate the MAPK signaling pathway and promote actin polymerization. SLP76/PCLγ2 causes Ca²⁺ influx. Furthermore, it leads to cellular degranulation and secretion of cytokines. PI3K can recruit PCL-γ, Rac1, and Akt signaling molecules to activate NK cell function. In addition, PI3K can recruit the SOS1-Grb2-Vav1 complex via SOS1 and recruit the small Ras-family GTPase Rap1 with the help of CrkL to achieve cytotoxicity.