High-Fructose Diet Increases Inflammatory Cytokines and Alters Gut Microbiota Composition in Rats

Figure 4

Effect of fructose in different dosages on the colon of rats. (a) Representative micrographs of HE-stained sections of rat colon (×40); (b) scores based on inflammatory cell infiltration in the colon. Data are presented as the (). means significantly different from the Con group; (c) Western blot bands of perilipin-1, ADRP, Tip-47, ZO-1, and occludin in the colon. Con group, administration of saline solution; Fru-L group, administration of a low dosage of fructose (2.6 g/kg/day); Fru-M group, administration of a moderate dosage of fructose (5.3 g/kg/day); Fru-H group, administration of a high dosage of fructose (10.5 g/kg/day).

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