Nicotine Impairs the Response of Lung Epithelial Cells to IL-22
Nicotine inhibits IL-22-mediated epithelial cell repair. Primary AECs were grown to 95% confluence on 12-well culture dishes that were then scratched and treated with IL-22+ (with)/- (without) nicotine 10 μM (Nic) at the concentrations shown. (a) Photomicrographs shown are 72 h later. (b) Quantitation of the data. Data is presented as the of 5 experiments using AECs from 2 different donors. Arrows point to the scratches. Scale for micrograph is 20 μm.
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