Nicotine Impairs the Response of Lung Epithelial Cells to IL-22
Downregulation of IL-22R expression on AECs by nicotine. Primary human AECs were exposed to nicotine 1-10 μM for 72 h. The expression of IL-22Rα1 as determined by (a) q-PCR. indicates that value is significant. (b) Flow cytometry. (c) Expression of IL-28rα by flow cytometry. Data is representative of 4 experiments with AECs from 2 different donors. Numbers on the histograms depict the MFI.
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