Mediators of Inflammation / 2020 / Article / Tab 1

Review Article

The Potential of Food Protein-Derived Bioactive Peptides against Chronic Intestinal Inflammation

Table 1

The in vitro effects of food-derived bioactive peptides on inhibiting inflammation.


CR, FL, HC, LL, MKEgg ovotransferrinTNF-α-induced Caco-2 cells0.05-2 mg/mL egg white digestReduce IL-8 secretion and expressions of TNF-α, IL-8, IL-6, IL-1β, and IL-12 and increase IL-10 expressionInhibit intestinal inflammation[17]
DEDTQAMPFR, DEDTQAMPF, MLGATSL, MSYSAGFEgg white proteinTNF-α-induced Caco-2 cells0.25 mg/mL peptideInhibit expressions of TNF-α, IL-8, IL-6, IL-1β, IL-12, JNK, IκB, and p38 and increase IL-10 expressionInhibit inflammation via the MAPK pathway[18]
DYKKYMilk whey proteinRAW 264.7 cells10 and 100 μg/mLInhibit expressions of IL-1β, COX-2, and TNF-α and productions of IL-1β and TNF-α and inhibit p38, p65, and IκBα degradationInhibit inflammation via the NF-κB pathway[19]
EAMAPK, AVPYPQMilk caseinH2O2-induced IEC-6 cells5-150 g/mL peptideReduce ROS levels and increase SOD and Nrf2 activitiesAntioxidation[13]
FLVSoybean proteinTNF-α-induced RAW 264.7 and 3T3-L1 cells0.1-1 μM FLVInhibit productions of TNF-α, IL-6, and MCP-1 and expressions of JNK, IKK, and IκBαInhibit inflammation[20]
GPETAFLRLupine proteinTHP-1-derived macrophages100-500 μg/mL GPETAFLRReduce expressions of TNF-α, IL-1β, and CCL2 and increase IL-10 expressionPrevent chronic inflammation[21]
GPRAmaranth proteinLPS-induced THP-1 and RAW 264.7 cells1 mg/mL hydrolysateInhibit TNF-α secretionInhibit inflammation via the NF-κB pathway[22]
IPAVMilk whey proteinTNF-α-induced Caco-2 cells25-200 μM IPAVReduce IL-8 and inhibit expressions of NF-κB, ERK1/2, JNK1/2, Syk, and p38Inhibit intestinal inflammation via PepT1[23]
IRWEgg ovotransferrinTNF-α-induced human endothelial cells50 μM IRWInhibit ICAM-1, VCAM-1, MCP-1, and NF-κB pathwayInhibit vascular inflammation[24]
IRW, IQWEgg ovotransferrinHUVECs50 μM IRW or IQWInhibit expressions of ICAM-1, VCAM-1, and NF-κB pathwayInhibit endothelial inflammation and oxidative stress[12]
LDAVNR, MMLDFSpirulina maximaRBL-2H3 mast cells and EA.hy926 cells200 μM peptideReduce histamine release, IL-8 production, and ROS productionInhibit inflammation[25]
LunasinDefatted soybean meal proteinLPS-induced RAW 264.7 cells100 μM lunasinInhibit NO and PGE2 production and COX-2 and iNOS expressionsInhibit inflammation[14]
PAYSalmon proteinLPS-induced RAW 264.7 cells0.25-0.75 mM PAYReduce productions or expressions of NO, PGE2, TFN-α, IL-6, IL-1β, iNOS, and COX-2Inhibit inflammation[26]
PRRTRMMNGGR, MGPAMMRTMPGJuice of cooked tunaLPS-induced RAW 264.7 cells100 μg/mL hydrolysateInhibit secretions of IL-2, TNF-α, and IFN-γInhibit inflammation[27]
QCQQAVQSAVRuditapes philippinarum hydrolysateLPS-induced RAW 264.7 cells10-100 μg/mL peptideInhibit NO productionInhibit inflammation[28]
QQQQQGGSQSQ, QEPQESQQ, QQQQQGGSQSQSQKG, PETMQQQQQQGerminated soybean proteinLPS-induced RAW 264.7 cells2 mg/mL fractionInhibit NO and PGD2 productionInhibit inflammation[29]
SSEDIKEAmaranth proteinCaco-2 cells100-200 μg/mL SSEDIKEReduce CCL20 and NF-κB expressionsInhibit inflammation[30]
VPPMilk casein3T3-L1 adipocyte cells1 mM VPPInhibit TNF-α expressionInhibit inflammation via ACE-dependent cascade[31]
VPP, IPPMilk casein3T3-F442A cells50 μM VPP or IPPUpregulate PPARγ, activate NF-κB, and reduce adipokineInhibit inflammation[32]
VPYSoybean proteinCaco-2 and THP-1 cells0.1-4 mM VPYInhibit IL-8 and TNF-α secretionsTreat IBD via PepT1[33]
VH, LAN, IA, ALVelvet antler protein from red deerLPS-induced RAW 264.7 cells100-500 μg/mL peptideInhibit NO productionInhibit inflammation[34]
β-Ala-HisMeat productsH2O2-induced Caco-2 cellsInhibit IL-8 and p38 and ERK activationInhibit inflammation via the MAPK and PepT1 pathways[35]
pyroGlu-LeuWheat glutenLPS-induced RAW 264.7 cells200-800 μg/mL peptideInhibit NO production, TNF-α, IL-6, and IκBα degradation, and JNK, ERK, and p38 phosphorylationInhibit inflammation via the NF-κB and MAPK pathways[36]

3T3-L1: mouse preadipocytes; ACE: angiotensin-converting enzyme; Caco-2: human colorectal adenocarcinoma-derived intestinal epithelial cells; COX-2: cyclooxygenase-2; EA.hy926: human umbilical vein endothelial cells; PPARγ: peroxisome proliferator-activated receptor gamma; RAW264.7: a mouse macrophage cell line; RAS: renin-angiotensin system; RBL-2H3: rat basophilic leukemia cells; ROS: reactive oxygen species; SOD: superoxide dismutase; THP-1: a human monocytic cell line; TNF-α: tumor necrosis factor α; HUVECs: human umbilical vein endothelial cells; ICAM-1: intercellular adhesion molecule-1; IL-1β: interleukin-1β; JNK: c-Jun N-terminal kinase; MAPK: mitogen-activated protein kinase; MCP-1: monocyte chemoattractant protein-1; NF-κB: nuclear factor-κB; NO: nitric oxide; VCAM-1: vascular cell adhesion molecule-1.

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